Locally advanced rectal carcinoma
Clinical trials for Locally advanced rectal carcinoma explained in plain language.
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Can a 16-Hour fast supercharge immunotherapy against rectal cancer?
Disease control Not yet recruitingThis phase II trial is testing whether a 16-hour fast before each dose of the immunotherapy drug serplulimab, combined with chemotherapy, can improve outcomes for people with a common type of locally advanced rectal cancer. The approach aims to boost the immune system's ability t…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase 2 • Sponsor: Zhejiang University • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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New adaptive radiation boosts rectal cancer response rates
Disease control Not yet recruitingThis study tests a personalized radiation approach for locally advanced rectal cancer. By adjusting the radiation dose halfway through treatment based on a special MRI scan, doctors hope to increase the number of patients whose tumors completely disappear before surgery. The tria…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Sponsor: IRCCS San Raffaele • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Triple chemo may help rectal cancer patients avoid surgery
Disease control Not yet recruitingThis Phase 3 trial tests whether a three-drug chemotherapy combination (FOLFOXIRI) works better than the standard two-drug combination (CAPOX/FOLFOX) for people with high-risk locally advanced rectal cancer. Both groups also receive chemoradiation, and then either surgery or a wa…
Matched conditions: LOCALLY ADVANCED RECTAL CARCINOMA
Phase 3 • Sponsor: J. W. A. Burger • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC