Stronger chemo may help avoid surgery in rectal cancer trial
NCT ID NCT07472868
First seen Mar 23, 2026 · Last updated May 23, 2026 · Updated 14 times
Summary
This study tests if a stronger chemotherapy combination (FOLFOXIRI) before standard chemoradiation leads to better tumor disappearance and quality of life compared to a standard combination (CAPOX/FOLFOX) in people with high-risk locally advanced rectal cancer. About 394 participants will receive one of the two chemo regimens, followed by radiation and possibly surgery or a watch-and-wait approach. The goal is to see if the stronger chemo increases the chance of avoiding surgery while keeping the cancer under control.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Catharina Hospital Eindhoven
Eindhoven, North Brabant, 5623 EJ, Netherlands
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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