LOCALLY ADVANCED RECTAL CANCER (LARC)
Clinical trials for LOCALLY ADVANCED RECTAL CANCER (LARC) explained in plain language.
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New combo therapy aims to save rectums in advanced cancer
Disease control Recruiting nowThis study tests whether a short course of radiation followed by chemotherapy and two immunotherapy drugs can help people with a certain type of locally advanced rectal cancer avoid surgery and keep their rectum. About 116 adults aged 18-75 with MSS or pMMR rectal cancer will tak…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Zhejiang University • Aim: Disease control
Last updated May 26, 2026 11:45 UTC
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New combo therapy aims to shrink rectal tumors before surgery
Disease control Recruiting nowThis study tests a new treatment plan for people with a certain type of locally advanced rectal cancer (MSS-type). The plan combines short-course radiation, chemotherapy, an immunotherapy drug (serplulimab), and a targeted therapy (bevacizumab) before surgery. The goal is to see …
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Disease control
Last updated May 26, 2026 11:37 UTC
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Real-world data on dostarlimab for rectal cancer: hope for tumor shrinkage without surgery?
Disease control Recruiting nowThis study looks at how well the drug dostarlimab works and how safe it is for people with a certain type of advanced rectal cancer (dMMR/MSI-H). Researchers will track 50 patients who receive the drug before any other treatment, using real-world data from a national registry. Th…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Sponsor: National Cancer Institute, Naples • Aim: Disease control
Last updated May 26, 2026 11:36 UTC
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Virus therapy joins chemo to fight rectal cancer
Disease control Recruiting nowThis trial tests a new treatment called NG-350A, a virus that targets tumor cells and boosts the immune system, combined with standard chemoradiotherapy. It is for adults with locally advanced rectal cancer who have a high risk of the cancer coming back. The goal is to see if thi…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase: PHASE1 • Sponsor: Akamis Bio • Aim: Disease control
Last updated May 18, 2026 12:02 UTC
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Blood test may predict who beats rectal cancer before surgery
Knowledge-focused Recruiting nowThis study is testing a new blood test that looks for cancer DNA to predict how well rectal cancer responds to treatment given before surgery. About 60 adults with locally advanced rectal cancer will provide blood and tissue samples at several time points. The goal is to build a …
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 11:28 UTC