Locally advanced rectal cancer (LARC)
Clinical trials for Locally advanced rectal cancer (LARC) explained in plain language.
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Virus therapy joins Chemo-Radiation in fight against rectal cancer
Disease control OngoingThis early-phase trial tests a new treatment called NG-350A, a virus designed to stimulate the immune system inside tumors, combined with standard chemoradiotherapy for people with locally advanced rectal cancer. The study aims to see if this combination can improve the chance of…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase 1 • Sponsor: Akamis Bio • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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New drug duo takes on tough rectal cancer
Disease control OngoingThis phase 2 trial is testing whether adding two drugs—a PCSK9 inhibitor and a PD-1 inhibitor—to standard chemoradiotherapy can help shrink tumors in patients with locally advanced rectal cancer that has a specific genetic profile (pMMR/MSS). The study involves 30 participants an…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Phase 2 • Sponsor: Guangdong Provincial People's Hospital • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New combo therapy aims to skip radiation for rectal cancer patients
Disease control OngoingThis study tests a new approach for people with locally advanced rectal cancer that has a common genetic profile (MSS/pMMR). Instead of standard radiation before surgery, participants receive a combination of chemotherapy (mFOLFOX6) and an immunotherapy drug (PD-1 antibody). The …
Matched conditions: LOCALLY ADVANCED RECTAL CANCER (LARC)
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC