LIVER FIBROSIS

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests whether phycocyanin, a natural protein from spirulina, can improve liver health in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness …

This study tests whether a low dose of thyroid hormone (Synthroid) can help Veterans with NASH, a serious liver condition that can lead to liver failure or cancer. About 128 overweight or obese Veterans with NASH will receive either the hormone or a placebo daily for 52 weeks. Th…

This study tests a medicine called survodutide, given as a weekly injection, in 1800 adults with NASH/MASH and moderate to advanced liver fibrosis. The goal is to see if it can improve or reverse liver damage and prevent progression to cirrhosis. Participants receive either survo…

This study tests an experimental drug called PHIN-214 in 74 adults with mild-to-moderate liver cirrhosis (Child-Pugh A or B). The goal is to find a safe dose and see how the body handles the drug. It is an early-phase trial focused on safety, not a cure.

This study is testing a new, fast MRI method to measure liver scarring (fibrosis) without needing a needle biopsy. The scan takes less than 8 seconds while you hold your breath. Researchers will compare the MRI results with standard tests in 200 adults with liver disease and heal…

This study is testing a new way to measure liver scarring (fibrosis) using a special ultrasound during an endoscopy. It involves 65 adults with chronic liver disease who are already scheduled for a liver biopsy. The goal is to see if this new method is as accurate as a biopsy and…

This study looks at whether magnetic resonance elastography (MRE), a special MRI that measures tissue stiffness, can accurately grade liver fibrosis (scarring) in people with chronic hepatitis B. Researchers will compare MRE results to standard liver biopsies in 600 adults. If su…

This study looks at liver tissue and blood from 240 people with various liver conditions, including fatty liver, hepatitis B, fibrosis, and cirrhosis. Researchers will use cutting-edge technology to study individual cells and their surroundings. The goal is to better understand h…

This early-stage study tests a single dose of an experimental drug (AZD2389) in 12 adults with advanced liver scarring (cirrhosis). The main goal is to see how well the drug attaches to its target in the liver using a special PET scan. This is not a treatment study; it is designe…

This study looks at a new way for family doctors to work with a hospital to find liver scarring (fibrosis) early. It will include 150 adults who are at risk due to alcohol, diabetes, or other factors. The goal is to see if patients get the right follow-up care after a simple, non…

This study looks at 320 people with HIV to create tools that can predict who will develop fatty liver disease or liver scarring. Researchers will track changes in liver health over time using ultrasound and a special scan called Fibroscan. The goal is to catch liver problems earl…

This study looks at using a special ultrasound (liver elastography) to measure liver scarring in children and young adults with type III glycogen storage disease. The goal is to see if this painless test can replace liver biopsies for monitoring. About 30 participants will have t…