LIVER FIBROSIS

This study tests a drug called hydronidone to see if it can stop or slow liver scarring (fibrosis) in people with chronic hepatitis B. About 1,200 adults aged 18-65 will take either hydronidone or a placebo, along with standard antiviral therapy, for up to 5 years. The goal is to…

This study aims to see if using a contrast-enhanced ultrasound called Sonazoid CEUS can detect early-stage liver cancer (HCC) better than standard ultrasound in people with liver cirrhosis. About 556 participants with cirrhosis will receive both types of ultrasound every 4 to 6 m…

This study looks at how the body handles a single dose of hydronidone in people with different levels of liver function. It includes 30 adults with either normal liver function or varying degrees of liver impairment. The goal is to understand how liver health affects drug levels …

This study tests two noninvasive ultrasound devices to measure liver stiffness and inflammation in people with fatty liver disease. About 95 adults will get same-day scans with both machines to see if results match. The goal is to find a painless way to assess liver damage withou…

This study will check how common fatty liver disease and liver scarring are in adults with type 1 diabetes or LADA in Quebec. About 100 participants will have a single visit for a liver scan and other tests. The goal is to find undiagnosed liver problems and see if body weight pl…

This early-stage study tests a higher dose of the drug hydronidone in 138 healthy Chinese adults. Researchers want to see how the body absorbs and processes the drug, and whether it is safe. This is not a treatment study; it gathers information to support future research on liver…

This study looks at whether common blood tests (hs-CRP, triglycerides, and glucose) can help detect liver fibrosis in people with non-alcoholic fatty liver disease (NAFLD). Researchers will enroll 96 adults and compare these blood markers with liver scans. The goal is to find a s…

This study looks at whether high uric acid levels (hyperuricemia) are linked to fatty liver disease and liver scarring in 111 obese adults. Researchers aim to understand this connection to help catch liver problems early and guide future treatments. Participants must be 18-65 yea…