Breath-Held MRI could replace painful liver biopsies
NCT ID NCT04429100
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new, fast MRI technique that measures collagen in the liver to detect scarring (fibrosis) without a needle biopsy. Researchers will compare the MRI results with standard tests in 200 adults with liver disease and healthy volunteers. The goal is to find a safer, more comfortable way to diagnose early-stage liver fibrosis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2020
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The patients referred to hepatology center affiliated to The Chinese University of Hong Kong (CUHK) will be enrolled in this study. The research team led by one hepatologist as one of our collaborators will be responsible for patient recruitment.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patient group * patients with histology-proven liver fibrosis, including those with liver fibrosis stage F0, early-stage liver fibrosis (F1-2), and late stage. liver fibrosis(F3-4). * patient aged 18 years old and above. 2. Healthy control group * controls aged 18 years old and above. Exclusion Criteria: * Contraindications to MRI, such as cardiac pacemaker, claustrophobia, pregnancy, metallic implants not suitable for MRI scan.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Chinese University of Hong Kong, Prince of Wale Hospital
RECRUITINGHong Kong, Shatin, Hong Kong
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Other studies related to the condition(s) this trial covers.
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- Can a new ultrasound device spot liver damage without a biopsy?
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- Can extra doses of an old drug reverse liver scarring?
- Can Weight-Loss surgery beat drugs for advanced liver damage?