KNEE PAIN CHRONIC

This study is testing a knee implant called Persona in 760 people who need knee replacement surgery due to arthritis or other knee problems. The goal is to see if the implant is safe, works well, and helps patients move better and feel less pain. Participants will be followed for…

This study tests whether shining a specific type of light (810 nm) on the knee can reduce pain and swelling in people with chronic knee pain and synovitis (inflammation of the joint lining). About 80 adults aged 40-80 will receive either real light therapy or a sham treatment twi…

This study looks at whether injecting the anti-inflammatory drug dexamethasone into a nerve block or into a vein works better for pain and swelling after total knee replacement. About 90 adults having knee surgery will be randomly assigned to one of the two methods. Researchers w…

This study tests a new approach called Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT teaches the brain to reinterpret pain signals, aiming to reduce pain without medication. About 110 participants will be randomly assigned t…

This study tests whether focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who also have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relieve…

This study looks at whether a brain MRI can predict if someone will be satisfied after knee replacement surgery. About 1 in 5 patients still have pain or trouble moving after surgery, and doctors can't predict who. Researchers will scan the brains of 50 adults before and after su…