KIDNEY TRANSPLANTATION

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This early-stage trial tests a new cell therapy called Eight Treg in 9 people receiving a kidney from a living donor. The therapy uses the patient's own immune cells, grown in a lab, to help the body accept the new kidney without strong anti-rejection drugs. The main goal is to c…

This study tests whether a stomach acid drug called vonoprazan fumarate can help transplanted kidneys start working sooner. About 47 adults receiving their first kidney from a deceased donor will take the drug daily for a week after surgery. The goal is to see if it reduces the n…

This study tests a treatment called extracorporeal phototherapy (ECP) for people whose kidney transplants are failing due to chronic antibody-mediated rejection. ECP involves taking a patient's blood cells, treating them with a light-activated drug and UVA light, then returning t…

This study tests a new drug called ALXN2030 in 45 adults who have had a kidney transplant and are experiencing antibody-mediated rejection (AMR). The goal is to see if the drug can help resolve signs of rejection seen on a kidney biopsy after one year of treatment. Participants w…

This study tests whether dipyridamole, a drug used for heart conditions, can raise phosphate levels in kidney transplant patients who develop low phosphate (hypophosphatemia). About 90 adult kidney transplant recipients will receive dipyridamole or a placebo. The goal is to see i…

This study tests a genetically modified pig kidney (called the 10 GE Xenokidney) in 50 adults with end-stage kidney disease who cannot get a human kidney transplant or face a long wait. The goal is to see if the pig kidney works safely and well, improving survival and quality of …

This study tests whether a specially modified pig kidney can safely work in people with end-stage kidney disease who cannot get a human kidney transplant. Up to 50 participants will receive the pig kidney and be followed for life. The goal is to see if the pig kidney can keep pat…

This study tests a new approach for people with end-stage kidney disease who have very high levels of antibodies, making it nearly impossible to find a compatible donor kidney. The treatment uses a strong medication regimen to wipe out the patient's existing immune cells, then re…

This study tests whether monitoring levels of a harmless virus called TTV can help doctors personalize immune-suppressing drugs for kidney transplant patients. The goal is to prevent long-term complications like infections, cancer, and organ rejection. About 600 adults who receiv…

This study looks at whether older kidney transplant patients (55+) can safely stop taking one of their anti-rejection drugs (mycophenolate mofetil) while still protecting their new kidney. About 350 participants will either stop the drug or continue standard care, and researchers…

This study tests whether a single infusion of specially grown immune cells (TRK-001) can help kidney transplant recipients safely reduce their lifelong anti-rejection medications. About 34 adults receiving a kidney from a living donor will either get standard care or standard car…

This study tests a 6-week online program called the Chronic Disease Self-Management Program (CDSMP) for people in Israel living with a kidney transplant or cancer. The program teaches practical skills like managing symptoms, setting health goals, and communicating with doctors. R…

This study looks at whether a 12-week home-based exercise program is safe and helpful for adults aged 60 and older who are waiting for a kidney transplant. Participants will either get usual care plus a fitness tracker, or usual care plus online exercise classes. The goal is to s…