KAPOSI SARCOMA

This study tests if propranolol, a safe, inexpensive oral drug used for heart conditions, can shrink Kaposi sarcoma tumors in adults. Kaposi sarcoma is a cancer linked to a virus, often affecting people with weakened immune systems. The trial aims to see if at least 45% of the 25…

This study tests a drug called ixazomib in people with Kaposi sarcoma, a type of skin cancer. The drug works by blocking enzymes that cancer cells need to grow. Researchers want to see if it can shrink tumors and will monitor side effects. About 41 adults with measurable skin les…

This study tests two non-chemotherapy drugs, PDS01ADC and M7824, for people with advanced Kaposi sarcoma (KS) that has not responded well to prior treatment. The drugs work by helping the immune system recognize and attack tumors. About 80 adults aged 18 and older will receive th…

This study tests a lab-made protein called CYT107 in 55 adults with HIV and Kaposi sarcoma, a cancer linked to a weakened immune system. The protein is given as weekly shots for up to 4 weeks to try to increase T cells and shrink tumors. Researchers will monitor how well it works…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This early-phase study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), for adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs shrink tumors. Up to 58 participants, i…

This study looks at whether peer education and support can help more adolescents and young adults (ages 15-39) living with HIV get screened for cancer and stick with their cancer treatment. Researchers will work with 4,100 participants in Zambia to improve early diagnosis and tre…

This study follows 150 adults with Kaposi sarcoma (KS), a tumor caused by a virus, to learn how the disease starts, changes, and may come back. Participants will have regular check-ups, scans, and biopsies over up to 10 years. The goal is to better understand KS, not to test a ne…