KAPOSI SARCOMA

This study tests a lab-made protein called CYT107 in 55 adults with HIV and Kaposi sarcoma (a skin cancer). The protein aims to boost the immune system by increasing T cells, which may help shrink tumors. Participants receive weekly injections for up to 4 weeks, with possible rep…

This phase 2 trial tests whether the drug ixazomib can shrink tumors in people with Kaposi sarcoma, a type of skin cancer. The drug works by blocking enzymes that cancer cells need to grow. About 41 adults with confirmed Kaposi sarcoma will take part to see if the treatment is ef…

This study tests whether propranolol, a safe oral drug already used for other conditions, can shrink Kaposi sarcoma tumors in adults. About 25 people with measurable skin lesions will receive the drug and be monitored for response and side effects. The goal is to see if at least …

This study tests the drug nivolumab in people with rare cancers that have spread and have not responded to standard treatments. It includes over 40 different rare tumor types, as long as the cancer cells have a specific marker called PD-L1. The goal is to see if nivolumab can shr…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This study tests two non-chemotherapy drugs, PDS01ADC and M7824, in people with advanced Kaposi sarcoma (KS). The drugs work by helping the immune system recognize and attack KS tumors. About 80 adults aged 18 and older whose KS has not responded well to prior treatment will rece…

This early-phase study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), for adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs shrink tumors. Up to 58 participants, i…

This study looks at whether peer education and support can help more adolescents and young adults (ages 15-39) living with HIV get screened for cancer and stick with their cancer treatment. Researchers will work with 4,100 participants in Zambia to improve early diagnosis and tre…

This study follows 150 adults with Kaposi sarcoma (KS), a tumor caused by a virus, to learn how the disease starts, changes, and may come back. Participants will have regular check-ups, scans, and biopsies over up to 10 years. The goal is to better understand KS, not to test a ne…