INSULIN SENSITIVITY

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests whether colchicine, an anti-inflammatory drug, can improve how well the body responds to insulin in people with type 1 diabetes who have low-grade inflammation. Researchers will measure insulin sensitivity using a special test. The trial involves 26 adults and co…

This study tests a new medicine called retatrutide in adults with type 2 diabetes. The goal is to see if it improves how the body makes and uses insulin compared to a placebo or another diabetes drug. About 95 people will take part, and they will continue their usual diabetes med…

This study looks at whether replacing sugary drinks with stevia-sweetened ones helps children ages 8 to 12 control their weight, blood sugar, and cholesterol. About 150 kids who currently drink sugary beverages will be assigned to drink either stevia-sweetened drinks, water, or s…

This study tests whether giving insulin once a week for up to 2 hours can improve how the body uses sugar and help thinking and memory in people with Alzheimer's disease. Eight adults with mild to moderate Alzheimer's will receive the treatment for 6 months and complete memory te…

This study looks at why night shift workers have higher risks for heart disease and diabetes. Researchers will test if eating only during a set window each day (time-restricted eating) can improve blood pressure, blood sugar control, and blood vessel health. The study involves 50…

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat sends out signals that make your muscles less responsive to insulin, and if weight loss can quiet those signals. About 70 adults with obesity will fo…

This study looks at whether two common artificial sweeteners, aspartame and sucralose, change how the body handles sugar in adults aged 40 and older who have prediabetes. Researchers will provide all meals for 8 weeks and track blood sugar levels continuously. The goal is to see …

This study looks at how a single bout of exercise improves the way muscles respond to insulin in healthy young men. Researchers will have participants do a one-legged knee exercise and then measure insulin sensitivity using a special clamp technique. The goal is to understand the…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…