HYPERTRIGLYCERIDEMIA

This study tests whether the experimental drug MAR001 can reduce blood fat (triglycerides) after a meal better than a placebo. About 30 adults with high triglycerides will receive either MAR001 or a placebo and have their fat levels measured after eating a mixed meal. The goal is…

This study tests an experimental drug called ION775 in 72 adults with high or very high triglycerides, a type of fat in the blood that can raise heart risk. Participants must already be on standard cholesterol-lowering medicines. The main goal is to see if ION775 safely reduces t…

This study tests a new injection called JMT202 in people with very high triglycerides, a type of fat in the blood that can raise heart risk. About 48 Chinese adults will receive either the drug or a placebo to check safety and how well it works. The goal is to see if the injectio…

This study tests the long-term safety and effectiveness of a drug called plozasiran in adults with very high triglycerides, a condition that raises the risk of pancreatitis and heart disease. About 869 participants who completed earlier studies will receive injections every 3 mon…

This study tests whether adding chia seeds and pumpkin seeds to a heart-healthy diet can lower triglyceride levels in people with hypertriglyceridemia (high blood fats). About 375 adults with moderately high triglycerides will eat either a standard healthy diet or the same diet p…

This early-stage study tests a single dose of VERVE-201, a gene-editing treatment, in 36 adults with high cholesterol and triglycerides that don't respond to standard therapies. The treatment aims to turn off a liver gene (ANGPTL3) to lower fat levels in the blood. The main goal …

This study tests an experimental drug called RBD5044 in 40 adults with high triglycerides, a type of blood fat that raises heart risk. Participants receive either the drug or a placebo twice over 12 weeks. The main goal is to see if RBD5044 safely lowers triglyceride levels.

This study is testing a new treatment called CTX310, which uses CRISPR gene editing to turn off a gene linked to high cholesterol and fats. It is for adults aged 18 to 75 whose lipid levels remain high despite standard treatments. The goal is to see if the therapy is safe and can…

This study aims to understand how two different fish oils, EPA and DHA, affect blood clotting and cholesterol in people with high triglyceride levels. Researchers will give participants either EPA or DHA supplements and track changes in blood tests over time. The goal is to gathe…

This study looks at how different types of insulin resistance affect the liver's fat production in people with high triglycerides. Researchers will measure fat production after a meal and see if a short exercise session before eating changes it. The goal is to understand the link…

This study is a registry that gathers health data from 500 people in Russia with extremely high triglyceride levels (≥10 mmol/L). It does not test any new treatment but aims to describe patient characteristics, genetics, and current care patterns. The information collected may he…

This study looks at whether high-speed centrifugation can remove fat from blood samples so doctors can accurately measure anti-Xa activity, a key test for monitoring blood thinners. About 150 adults on anticoagulants will have their blood samples tested. The goal is to see if thi…