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Fish oil Face-Off: EPA vs. DHA for better heart health

NCT ID NCT06494488

Knowledge-focused Sponsor: The Miriam Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study is testing two types of fish oil—EPA and DHA—to see how they affect blood clotting and cholesterol in people with high triglycerides. Eighty participants will take one of the two oils for a month and have their blood tested. The goal is to learn which oil might be better for heart health, but it's too early to draw firm conclusions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fish oil (eicosapentaenoic acid and docosahexaenoic acid)
What this could lead to
If successful, this could help clarify which type of fish oil is better for heart health in people with high cholesterol.
What could go wrong
This is a very early, small study (80 people) that only looks at blood markers, not actual heart attacks or strokes. Results may not lead to clear treatment changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 69 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Fasting TG levels ≥ 150 mg/dL and \< 500 mg/dL and HDL-C ≤ 40 (men) or ≤ 50 (women) * LDL-C \> 40 mg/dL and ≤ 130 mg/dL * Able to provide informed consent and adhere to study schedules * Agree to follow and maintain a relatively stable and low fatty fish intake diet (\<3 servings per week) Exclusion Criteria: * Female with pregnancy, planned pregnancy (within the study period), or currently breastfeeding. * Subjects with weight changes greater than 20% over the past 3 months * Subjects planning a significant change in diet or exercise levels * Malabsorption syndrome and/or chronic diarrhea * Use of dietary supplements containing n-3 PUFA fatty acids * Frequent consumption of n-3 PUFA-enriched fish (\>3 times a week) * Abnormal liver, kidney, or thyroid functions * Drug or alcohol abuse within 6 months or significant mental/psychological impairment * Current smokers * Subjects taking daily aspirin, NSAIDs, anticoagulant, or corticosteroids * Subjects with known bleeding disorders (for example, hemophilia) * Known sensitivity or allergy to fish, shellfish, or omega-3 fatty acid supplements * Subjects requiring regular transfusions for any reason * No ethnic/racial groups will be excluded

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia inherited lipid metabolism disorder Lipid Metabolism Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertriglyceridemia Lipid metabolism disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Brown University Health - Lipid Clinic

    RECRUITING

    Providence, Rhode Island, 02914, United States

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