Fish oil pills put to the test: can they tame high triglycerides?
NCT ID NCT05015348
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial tests whether adding omega-3 supplements to a healthy lifestyle program can lower fasting triglycerides in adults with mild-to-moderate high blood fats. Participants are randomly assigned to receive either omega-3 capsules or a placebo (corn oil) for 12 weeks, while all receive nutritional counseling. Researchers will measure changes in blood fats, weight, and body composition to see if the supplements provide an extra benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- omega-3 polyunsaturated fatty acid (EPA and DHA) supplements
- What this could lead to
- If effective, this could offer a simple, natural way to improve heart health by lowering blood fats.
- What could go wrong
- This is a small, early-stage trial, and the placebo uses corn oil, which may also affect fat levels. Results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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127 people
The number who actually took part.
- Started
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Dec 2021
- Finished
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Dec 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 79 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \[1\] Gender and age: male or female, 18 years old and above. * \[2\] Patients were diagnosed with hyperlipidemia. According to the definition of the 2016 guidelines for the prevention and treatment of dyslipidemia in Chinese adults, it meets the clinical diagnostic criteria of mild-moderate hyperlipidemia: hypertriglyceridemia \[TG 1.7-5.4mmol/L\]; Or mixed with TC≥5.2mmol/L\]; Or mixed with LDL-C≥3.4mmol/L\]. * \[3\] Before the study, the subjects fully understood and voluntarily signed the informed consent form, and fully understood the research content, process, and possible adverse reactions. * \[4\] Those who can eat orally. * \[5\] Be able to complete the research according to the requirements of the research protocol and obey the arrangements of doctors and researchers. Exclusion Criteria: * \[1\] Those who are receiving lipid-lowering drugs. * \[2\] Hyperlipidemia caused by secondary causes, such as nephrotic syndrome, hypothyroidism, renal failure, liver disease, systemic lupus erythematosus, glycogen accumulation, myeloma, fat atrophy, acute porphyria, polycystic ovary syndrome, etc; Use diuretics, non-cardiac selective β-receptor blockers, and glucocorticoids, which may cause secondary dyslipidemia. * \[3\] Patients with severe internal and external diseases, such as heart, liver, and kidney dysfunction, acute myocardial infarction, stroke, intracerebral hemorrhage, acute attack of COPD, respiratory failure, etc., in recent 3 months, patients who have undergone surgery in the past 3 months, or any person who is not suitable to participate in this study after clinician evaluation. * \[4\] Have hemorrhagic disease or bleeding tendency. * \[5\] Those who have a history of allergy to omega-3 polyenoic acid preparation. * \[6\] Pregnant and lactating women. * \[7\] Poor compliance, unable to follow up on time or unable to complete the follow-up of medication. * \[8\] In the course of diagnosis and treatment, if there is any seriously abnormal metabolism or further intervention is needed, or the patient is no longer suitable for continuing the study through the assessment of the competent physician, he can withdraw from the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Peking Union Medical College Hospita
Beijing, Beijing Municipality, 100730, China
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