HPV positive oropharyngeal squamous cell carcinoma
Clinical trials for HPV positive oropharyngeal squamous cell carcinoma explained in plain language.
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Blood test could guide cancer treatment, reducing side effects
Disease control Not yet recruitingThis study tests whether a blood test that detects HPV DNA can help doctors choose the right treatment for people with HPV-positive oropharyngeal cancer. About 116 participants with stage I to III cancer will receive either the immunotherapy drug pembrolizumab (Keytruda) or stand…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase 2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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New combo aims to tame HPV throat cancer with fewer side effects
Disease control Not yet recruitingThis early-phase trial tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation to the neck can safely and effectively treat early-stage HPV-positive throat cancer before surgery. About 35 participants will take the drug daily for 10 days and receive …
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase 1/2 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New Vaccine-Drug combo aims to tame HPV throat cancer with less radiation
Disease control Not yet recruitingThis study tests a new treatment plan for people with HPV-positive oropharyngeal cancer (a type of throat cancer linked to HPV). The plan combines an immune-boosting drug (nogapendekin alfa inbakicept), a vaccine targeting HPV, chemotherapy, and a lower dose of radiation. The goa…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase 2 • Sponsor: ImmunityBio, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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MRI scans may reveal which throat cancer patients need stronger treatment
Diagnosis Not yet recruitingThis study tests whether special MRI scans can predict how well HPV-positive throat cancer responds to standard chemotherapy and radiation. Researchers will scan 30 adults before treatment and track their outcomes. The goal is to see if MRI patterns can identify low-risk patients…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Diagnosis
Last updated Sep 03, 2026 00:00 UTC
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Could less radiation be just as effective for HPV throat cancer?
Symptom relief Not yet recruitingThis study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 pa…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase 2 • Sponsor: University of Maryland, Baltimore • Aim: Symptom relief
Last updated Aug 16, 2026 00:00 UTC