HIP FRACTURES

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women aged 65–92 who have already broken a hip due to osteoporosis. About 2,400 women will be randomly assigned to receive the procedure or standard care, and they will be follo…

This study looks at whether having hip fracture surgery sooner (within hours) can lower the chance of death within 90 days for patients who also have a recent heart injury. About 1,100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) wil…

This study compares two surgeries for a certain type of hip fracture: using a metal nail inside the bone versus replacing the hip joint. The goal is to see which approach helps people move better, have less pain, and avoid needing another surgery. The study includes 170 adults ag…

This study follows 368 adults who need a partial hip replacement (hemiarthroplasty) using Corin devices. It aims to check how safe and effective the implants are over 10 years, focusing on complications and mobility. Participants have conditions like hip fractures, arthritis, or …

This study looks for a hidden spine condition called cervical myelopathy in people who broke a hip from a simple fall. Researchers will check 75 patients with a history, physical exam, and MRI if needed. The goal is to find and treat this condition early to help prevent more fall…

This study compares a new local numbing technique (PENG block) to standard spinal anesthesia for adults having hip replacement surgery. Researchers want to see if the new method controls pain just as well while allowing patients to move their leg sooner. About 100 participants wi…

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they arrive. Researchers will measure pain score…

This study tests if freezing a specific nerve group (cryoablation) provides better pain control 30 days after hip fracture surgery compared to a standard nerve block (fascia iliaca catheter). About 150 adults aged 18-85 having hip fracture repair will take part. The goal is to se…

This study compares two pain management methods for hip fracture surgery: standard multimodal analgesia versus a pericapsular nerve group (PENG) block. Researchers will measure pain scores, opioid use, how soon patients can walk, and hospital stay length. The goal is to see if th…

This study tests whether a long-acting form of the anesthetic bupivacaine (liposomal bupivacaine) plus regular bupivacaine provides better pain relief after hip replacement than the standard drug ropivacaine. About 60 adults with hip fractures or hip disease will receive one of t…

This study tests whether giving a combination of two medicines (esketamine and dexmedetomidine) during hip fracture surgery can improve sleep quality afterward in patients aged 65 and older. Half of the 96 participants will receive the drug combo, and the other half will receive …

This study tests whether a newer anesthetic drug, remimazolam, causes less confusion (delirium) after hip or knee surgery in elderly patients compared to the standard drug propofol. Researchers will enroll 82 older adults undergoing these surgeries and check for confusion three d…

This study tests whether a mobile app can help people recovering from hip, knee, or spine surgery do simple exercises while still in bed. About 100 adults will use the app to guide their in-bed conditioning, and researchers will measure how well they perform in physical therapy a…

This study looks at whether giving two doses of tranexamic acid, instead of one, can safely reduce blood loss and the need for blood transfusions in older adults (65+) having surgery for certain hip fractures. Participants will receive either one dose before surgery or two doses …

This study compares a new surgical implant (three screws locked together by a plate) with standard screws for fixing hip fractures in adults aged 18-64. The goal is to see which method keeps the broken bone more stable during healing. 75 participants will be followed for one year…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung problems after delayed hip surgery in people aged 65 and older. About 40 participants will be assigned to one of the two anesthesia types. The goal is to help doctors choose the safer option f…

This study looks at whether a simple bedside conversation guide can help older adults (age 50+) and their doctors make better decisions together about anesthesia for hip fracture surgery. About 1,881 patients at 6 hospitals will take part. The goal is to see if the tool improves …

This study translates and adapts the Groningen Frailty Indicator (GFI) questionnaire for Greek-speaking patients over 65 who have had hip fracture surgery. Researchers will enroll 89 participants to ensure the tool is culturally appropriate and accurate. The goal is to better ide…

This study looks at bone marrow from 24 adults aged 65 and older who are having hip surgery. Researchers will analyze the samples to see how metabolism and gene activity differ in stem cells with certain age-related mutations. The goal is to better understand clonal hematopoiesis…