HFPEF
Clinical trials for HFPEF explained in plain language.
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New drug combo aims to ease double Heart-Lung strain
Disease control Recruiting nowThis study tests whether adding macitentan to the standard drug dapagliflozin helps people with a specific type of heart failure that also affects the lungs. About 64 adults in South Korea will take the combination or a placebo for 24 weeks. Researchers will measure changes in bl…
Matched conditions: HFPEF
Phase: PHASE4 • Sponsor: Gachon University Gil Medical Center • Aim: Disease control
Last updated May 22, 2026 13:53 UTC
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New triple therapy aims to improve heart function in advanced heart failure patients
Disease control Recruiting nowThis study tests whether a combination of three heart medications (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and exercise capacity in 50 people with advanced heart failure with preserved ejection fraction (HFpEF). Participants will receive either the …
Matched conditions: HFPEF
Phase: PHASE2 • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated May 22, 2026 13:52 UTC
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Pacemaker tweak may ease breathing in heart failure patients
Symptom relief Recruiting nowThis study looks at whether changing the pacemaker settings in people with a type of heart failure (HFpEF) can lower pressure in the heart during light exercise, like cycling. The heart in HFpEF has trouble relaxing, causing pressure to build up and leading to shortness of breath…
Matched conditions: HFPEF
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Symptom relief
Last updated May 26, 2026 11:04 UTC
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Can leg exercises fix blood flow problems in veterans with heart failure?
Knowledge-focused Recruiting nowThis study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy people, then have the veterans do 8 weeks of knee exercises to see if it im…
Matched conditions: HFPEF
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 26, 2026 11:01 UTC
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Can we predict heart failure worsening? 500 patients tracked for answers
Knowledge-focused Recruiting nowThis study follows 500 people with a type of heart failure called HFpEF to find clues that predict serious problems like hospitalization or death. Researchers will review medical tests and check-ups done between 2013 and 2020, then track each person for at least 3 years. No new t…
Matched conditions: HFPEF
Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Knowledge-focused
Last updated May 22, 2026 14:04 UTC