HER2-positive metastatic breast cancer
Clinical trials for HER2-positive metastatic breast cancer explained in plain language.
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Can a RAGE inhibitor revive a failing breast cancer treatment?
Disease control Not yet recruitingThis trial is testing whether adding azeliragon, a RAGE inhibitor, to the drug T-DXd can help people with HER2-positive or HER2-low metastatic breast cancer whose cancer has progressed despite prior T-DXd treatment. The study will first find the safest dose of the combination, th…
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Phase 1/2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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New drug challenger takes on leading therapy for advanced breast cancer
Disease control Not yet recruitingThis study tests whether a new drug, trastuzumab rezetecan, works as well as or better than the current drug trastuzumab deruxtecan for women with advanced HER2-positive breast cancer that has worsened after previous treatment. About 100 women will be randomly assigned to one of …
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Phase 2 • Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Kazakhstan cancer study to reveal Real-World treatment patterns
Knowledge-focused Not yet recruitingThis study will review medical records of about 240 adults in Kazakhstan with HER2-positive metastatic breast cancer to see how they were treated and how well they did. Researchers will look at treatments given in routine care (except one specific drug) and track outcomes like ho…
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC