HER2
Clinical trials for HER2 explained in plain language.
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New hope for hard-to-treat ovarian cancer: targeted drug combo enters trial
Disease control Recruiting nowThis study tests a new two-drug combination for people with advanced ovarian cancer that has a specific protein called HER2. The drugs are distamab vedotin (a targeted therapy) and carboplatin (a standard chemo). The goal is to see if this combo works better and causes fewer side…
Matched conditions: HER2
Phase: PHASE2 • Sponsor: Zhejiang Cancer Hospital • Aim: Disease control
Last updated May 26, 2026 07:38 UTC
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New pill takes aim at hard-to-treat cancers with HER2 mutations
Disease control Recruiting nowThis early-stage study is testing an experimental drug called CGT4255 in about 100 adults whose advanced solid tumors have specific genetic changes (ERBB2 alterations or HER2 overexpression). The main goals are to check safety, find the best dose, and see if the drug shrinks tumo…
Matched conditions: HER2
Phase: PHASE1 • Sponsor: Cogent Biosciences, Inc. • Aim: Disease control
Last updated May 19, 2026 11:47 UTC
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New pill takes on hard-to-treat HER2 cancers, including brain tumors
Disease control Recruiting nowThis early-phase trial tests an experimental drug called IAM1363 in people with advanced cancers that have HER2 alterations. The study aims to find a safe dose and see if the drug can shrink tumors, including those that have spread to the brain. About 383 adults whose cancer has …
Matched conditions: HER2
Phase: PHASE1 • Sponsor: Iambic Therapeutics, Inc • Aim: Disease control
Last updated May 18, 2026 12:10 UTC
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New hope for hard-to-treat cancers: triple therapy targets HER2-positive tumors
Disease control Recruiting nowThis study tests a combination of two targeted drugs (trastuzumab and serplulimab) plus chemotherapy in 20 adults with advanced bile duct or bladder cancers that have stopped responding to standard treatments. The goal is to see if this triple therapy can shrink tumors and improv…
Matched conditions: HER2
Phase: PHASE2 • Sponsor: Xiujuan Qu • Aim: Disease control
Last updated May 11, 2026 20:48 UTC
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New PET tracer could sharpen view of HER2 cancers
Diagnosis Recruiting nowThis early study tests a special radioactive tracer called [68Ga]Ga-ABY-025 for PET scans. The goal is to see if it can better find and show HER2-positive tumors in people with advanced or metastatic cancer who are already receiving standard HER2-targeted therapy. About 30 adults…
Matched conditions: HER2
Phase: EARLY_PHASE1 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Diagnosis
Last updated May 26, 2026 07:24 UTC
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Italian study maps rare HER2 mutations in advanced lung cancer
Knowledge-focused Recruiting nowThis study is observing people with advanced non-small cell lung cancer (NSCLC) in Italy to find out how common HER2 mutations are and how doctors currently treat them. About 50 participants will be followed for one year. The goal is to gather real-world information, not to test …
Matched conditions: HER2
Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica • Aim: Knowledge-focused
Last updated May 26, 2026 07:26 UTC