HEALTHY CONTROLS

This study explores whether very small, barely noticeable movements can help retrain the brain's balance system in people with inner ear disorders. Researchers will test balance and motion sensitivity in 48 adults with vestibular hypofunction or healthy controls. The goal is to s…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than standard scans to detect neuroendocrine tumors. Researchers will scan 200 healthy volunteers and tumor patients using a high-sensitivity scanner and a tracer that targets tumor proteins. The g…

This early study is testing whether a personalized form of brain stimulation, called tACS, is safe and tolerable for pregnant women with depression. The treatment uses a mild electrical current to gently stimulate the brain based on each person's unique brain activity. The goal i…

This study tests whether a technique called Graded Motor Imagery (GMI) — a series of mental exercises — can reduce pain, stiffness, and feelings of instability in people with chronic ankle instability. Researchers will compare results from 48 participants (half with ankle instabi…

This study looks at whether a single session of whole-body heat therapy, with or without a cold water plunge, can reduce symptoms of depression. Researchers will enroll 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive…

This study tests a new, non-invasive brain stimulation technique called tIS in 10 healthy adults. Researchers want to see if it's safe and can change how the brain processes emotions, like recognizing faces. The goal is to gather information that could lead to better treatments f…

This study aims to understand why people with Lewy body dementia (including Parkinson's disease dementia) have sudden changes in attention and thinking, called cognitive fluctuations. Researchers will use brain scans, EEG (a test that records brain waves), and thinking tests in 1…

This study looks at how a substance called HA35 affects muscle protein balance in healthy adults. Twenty-four participants will take either HA35 or a placebo for three days, then undergo medical tests, muscle biopsies, and a gut permeability test. The goal is to understand how HA…

This study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy adults of similar age) during a single lab visit. The goal is to see if …

This early-phase study at Massachusetts General Hospital is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. The study includes 40 people aged 50-80 with Parkinson's disease, multiple system …

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, daily function, and emotional well-being. Researchers will compare 30 adults with these conditions to healthy volunteers using simple t…

This study uses brain scans and machine learning to understand why people with bipolar disorder experience rapid mood swings. Researchers will compare 72 adults with bipolar disorder and healthy controls while they recall memories and practice boosting positive emotions. The goal…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study uses a special PET scan to measure the density of synapses (connections between brain cells) in people with cocaine use disorder compared to healthy volunteers. Researchers aim to understand how cocaine affects brain plasticity. The study involves 80 participants aged …

This study is creating a large collection of samples—like stool, saliva, blood, and skin cells—from up to 600 people of all ages, both healthy and with various conditions. Researchers will use these samples to learn how the tiny organisms living in and on our bodies (the microbio…

This study looks at how haloperidol, an antipsychotic medication, may interfere with insulin's normal action in the brain. Insulin helps control blood sugar and supports brain function, but long-term use of haloperidol can lead to weight gain and diabetes. Researchers will give h…

This study uses low-intensity focused ultrasound to safely and temporarily change how different parts of the brain communicate in healthy volunteers. Researchers will test different doses to see which has the strongest effect on brain networks linked to mood and anxiety. The goal…