HEAD & NECK CANCER

This pilot study is testing whether giving a combination of two targeted drugs (nimotuzumab and toripalimab) plus standard chemotherapy before surgery can help shrink locally advanced tonsillar cancer. Ten adults with resectable tumors will receive the treatment for 2-4 cycles be…

This phase II trial tests whether adding nimotuzumab and immunotherapy to standard chemotherapy before surgery can improve outcomes for people with locally advanced head and neck cancer. About 182 participants will receive either the combination or standard treatment. The main go…

This early-stage study tests a new approach for people with head and neck cancer that has come back or spread. It combines a gene therapy injection (EDS01) given directly into a tumor with an immunotherapy drug (toripalimab) given through a vein. The main goal is to check safety …

This study tests a new drug (RiMO-301) given with targeted radiation and an immunotherapy drug (a PD-1 inhibitor) for people with advanced head and neck cancer that cannot be removed by surgery or has spread. The goal is to find the safest dose and see if the combination can shri…

This study tests a new drug called OM-RCA-01 in people with several types of cancer that have spread to other parts of the body and have a specific marker (FGFR1). The drug is an antibody given through a vein every two weeks. The main goals are to find a safe dose and see if it c…

This early-stage trial tests a new drug, VLPONC-01, injected directly into tumors in people with head and neck cancer. The study aims to see if it is safe and whether combining it with an immunotherapy drug (pembrolizumab) can shrink tumors better than the immunotherapy alone. Ab…

This phase 3 trial tests a new treatment for people with high-risk head and neck cancer who cannot receive the standard chemotherapy drug cisplatin. Participants receive radiation therapy combined with two drugs (nimotuzumab and benmelstobart) to see if this approach improves dis…

This study tests whether adding the targeted drug nimotuzumab to standard radiation therapy helps control advanced head and neck cancer better than radiation alone. It is for 335 adults whose cancer has spread locally but who cannot take platinum-based chemotherapy. The main goal…

This early study is testing a new imaging agent called FL-261 in 12 people with advanced cancers like lung, colorectal, or head & neck cancer. The agent targets a protein called c-MET that is often found on cancer cells. Researchers want to see if FL-261 scans can safely and accu…

This study tests if a special ultrasound using a contrast agent (Sonazoid) can find sentinel lymph nodes as accurately as the standard radioactive tracer method in people with melanoma, breast cancer, or head & neck cancer. About 91 adults will take part, and the goal is to see i…

This study tests whether a special PET-CT scan (micro-PET-CT) can accurately show where head and neck cancer ends, compared to standard lab tests. Ten adults with operable head and neck tumors will have their surgical specimens scanned and then checked under a microscope. If succ…

This early-stage study tests a non-invasive procedure that uses focused ultrasound to create a tiny lesion in the brain's pain center. It is for 20 adults with head, neck, or brachial cancer whose pain is not controlled by opioids. The goal is to see if it is safe and can reduce …

This study is testing whether a special nurse-led care plan can help people recover better after head and neck cancer surgery. The plan includes extra support from nurses, dietitians, and counselors to reduce complications and improve quality of life. About 80 adults having surge…

This study looks at genetic and immune changes in laryngeal dysplasia, a precancerous condition of the voice box. Researchers will compare tissue samples from 3 patients to see if certain immune cells (TILs) differ between low-risk and high-risk lesions. The goal is to find marke…

This study looks at using proton therapy for people whose head and neck cancer has come back in an area already treated with radiation. Since surgery is often not possible and standard radiation can harm healthy tissues, proton therapy may deliver the radiation more precisely. Re…

This study looks at whether giving written, guideline-based information to head and neck cancer patients and their dentists can improve their knowledge and decisions about dental care. About 132 participants will fill out surveys before and after reading the materials. The goal i…

This study is testing whether a special PET scan taken 6 weeks after starting pembrolizumab (an immunotherapy drug) can predict how well the drug works at 3, 6, and 9 months in people with advanced head and neck cancer. Researchers will enroll 25 patients whose cancer has returne…