GLIOBLASTOMA (GBM)

This phase 2 trial tests whether adding silevertinib, an oral drug that targets a specific protein (EGFR), to standard chemotherapy (temozolomide) helps people with a newly diagnosed, aggressive brain cancer called glioblastoma. The study includes 162 participants whose tumors ha…

This early-phase trial is testing an investigational drug called risvutatug rezetecan in 15 people with recurrent glioblastoma or brain metastases. The drug is designed to seek out and deliver a cancer-killing payload to tumor cells. The study first measures how much drug gets in…

This early-stage trial tests whether injecting an oncolytic virus directly into brain tumors can treat recurrent glioblastoma, a fast-growing cancer. Twenty participants will receive up to six injections over several weeks, with regular checkups to monitor safety and tumor respon…

This study tests whether a higher daily dose of radiation over three weeks can improve survival for people aged 65 and older with newly diagnosed glioblastoma, an aggressive brain cancer. Participants will be randomly assigned to receive either the standard radiation dose or an e…

This study tests a new drug, TLX101-Tx, that delivers radiation directly to glioblastoma cells. It is combined with standard chemotherapy (lomustine) and compared to chemotherapy alone in 50 adults whose brain cancer has returned after initial treatment. The goal is to see if the…

This study is for children and teens (ages 3 to 18) with certain solid tumors that have returned or not responded to standard treatment. The tumors must have a specific marker called SSTR. The study combines two drugs: Lutathera (a radioactive drug that targets SSTR) and Olaparib…

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can help control glioblastoma that has spread to the brain's lining or fluid spaces. About 38 adults with newly diagnosed, aggressive brain tumors will receive standard radiation and ora…

This study is for people with glioblastoma, a fast-growing brain cancer. It tests a new way to give radiation therapy that adapts to changes in the tumor and uses smaller treatment areas. The goal is to see if this approach can better control the cancer and improve survival compa…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions: one helps a common drug kill cancer cells, and the other wakes up the immune system to attack…

This study tests whether giving G-CSF (a drug that boosts white blood cells) during standard chemoradiation can help preserve brain volume and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be randomly a…

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This study tests whether adding a new immune cell treatment (DOC1021) to standard therapy helps people with a newly diagnosed, aggressive brain cancer called glioblastoma live longer. About 180 adults will either get the immune treatment plus standard care, or standard care alone…

This early-phase trial tests a new treatment for newly diagnosed glioblastoma, a fast-growing brain cancer. The therapy uses donor stem cells that carry a 'suicide gene' and are injected into the brain after tumor removal. The goal is to see if it is safe and can kill leftover ca…

This study tests a new drug called MT-125 given together with standard radiation for people newly diagnosed with a fast-growing brain tumor called glioblastoma. The main goals are to find a safe dose and understand side effects. About 36 adults aged 18 and older with a specific t…

This study looks at whether taking a common chemotherapy pill (temozolomide) in the morning or evening is easier for people with glioblastoma, a type of brain cancer. About 50 adults who have already had surgery and radiation will be randomly assigned to take their medication eit…

This study tests whether a substance called 5-ALA, already used during brain surgery to make tumor cells glow, can also be detected in blood or urine. Researchers hope this 'liquid biopsy' could help diagnose and monitor glioblastoma, the most common and deadly brain tumor, witho…

This study is developing an AI-powered blood test to detect several cancers early and monitor how well treatments are working. Researchers will analyze blood samples from 6,000 adults with or without cancer to find unique RNA markers in platelets and immune cells. The goal is to …

This study is testing whether a program called FearLess can help reduce the fear of cancer returning in people with primary malignant brain tumors and their caregivers. Researchers want to see if the program is practical and acceptable to participants. The study involves about 11…

This study aims to understand why some people with glioblastoma, a serious brain cancer, may think about or attempt suicide. Researchers will use questionnaires to track depression, anxiety, and quality of life in 176 patients across Germany. The goal is to identify warning signs…

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…