GIANT CELL ARTERITIS (GCA)

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra). About 78 adults who have been on high-dose tocilizumab for at least a year and off steroids for three months will either stop the …

This study looks at whether two medications, dapagliflozin and bosentan, can improve blood vessel function in people with large vessel vasculitis (LVV), a condition that raises the risk of heart attacks and strokes. About 60 adults with stable LVV will take both drugs for 6 weeks…

This study is testing a new blood-based test that aims to predict which medication will work best for each person with an autoimmune rheumatic disease like rheumatoid arthritis or lupus. Researchers will take a blood sample and expose the cells to different drugs in the lab to se…

This study is testing whether measuring the optic nerve sheath with ultrasound can reliably diagnose giant cell arteritis (GCA), a condition that can cause blindness. Researchers will compare ultrasound measurements to the final diagnosis made by a specialist after 6 months. The …

This study looks at whether measuring a protein called thrombomodulin in the blood can help doctors know if a person with polymyalgia rheumatica (PMR) also has giant cell arteritis (GCA), a more serious condition that can cause blindness or stroke. About 78 adults over 50 with PM…

This study tests whether a low dose of hydrocortisone (a cortisol-like hormone) can reduce symptoms like fatigue and dizziness in people who have recently stopped taking prednisolone for giant cell arteritis or polymyalgia rheumatica. About 100 adults aged 50 and older will recei…

This study tests whether ultrasound scans and patient questionnaires can better track disease activity in people with giant cell arteritis, a condition that inflames arteries and can cause blindness. Researchers will follow 175 patients in remission for one year, using ultrasound…

This study looks at two conditions that can cause sudden vision loss: giant cell arteritis (GCA), a blood vessel inflammation that needs urgent treatment, and NAION, a similar condition that does not benefit from that treatment. Researchers will use special PET/MRI scans and eye …

This study is looking for 340 people with suspected giant cell arteritis (GCA), a condition that causes inflammation in blood vessels and is usually treated with long-term steroids. The goal is to find better ways to predict who will have relapses and to monitor the disease using…