GIANT CELL ARTERITIS (GCA)

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra) without the disease coming back. About 78 adults who have been on high-dose tocilizumab for at least a year and off steroids for 3 …

This study tests whether two drugs, dapagliflozin and bosentan, can improve blood vessel function in people with large vessel vasculitis (LVV), a condition that raises the risk of heart attacks and strokes. About 60 adults with stable LVV will take both drugs for 6 weeks, then da…

This study aims to develop a blood test that can predict which medication will work best for each person with a rheumatic disease like rheumatoid arthritis or lupus. Researchers will take a blood sample and test how immune cells react to different drugs in the lab. The goal is to…

This study looks at whether measuring the optic nerve sheath with ultrasound can help diagnose giant cell arteritis (GCA), a condition that causes inflammation in blood vessels and can lead to vision loss. Researchers will enroll 190 people over age 50 with suspected GCA. The ult…

This pilot study is looking for a blood marker (thrombomodulin) that can tell whether a person with polymyalgia rheumatica (PMR) also has giant cell arteritis (GCA), a more serious condition that can cause blindness or stroke. Researchers will measure thrombomodulin levels in 78 …

This study tests whether a low dose of hydrocortisone can relieve symptoms like fatigue and dizziness in people who have stopped taking steroids for giant cell arteritis or polymyalgia rheumatica. About 100 adults aged 50 and older will receive either hydrocortisone or a placebo …

This study looks at better ways to track disease activity in people with giant cell arteritis, a condition that causes inflammation in blood vessels. Researchers will use ultrasound scans, patient questionnaires, and blood tests to see if they can predict when the disease will fl…

This study is looking for 340 people with suspected giant cell arteritis (GCA), a condition that causes inflammation in blood vessels and is usually treated with long-term steroids. The goal is to find better ways to predict who will have relapses and to monitor the disease using…

This study uses special PET/MRI and eye scans to look for inflammation in the small blood vessels around the eye in people with sudden vision loss. The goal is to better distinguish between giant cell arteritis (GCA), which needs urgent anti-inflammatory treatment, and a similar …