FRONTOTEMPORAL DEMENTIA

This study tested a drug called TPN-101 in 42 people with ALS or frontotemporal dementia caused by a specific gene change (C9orf72). The main goal was to check if the drug is safe and tolerable over 48 weeks. Researchers also looked at how the drug moves in the body and whether i…

This study tested a drug called AL001 in 33 people who carry a gene mutation that causes frontotemporal dementia, a brain disease that affects personality and language. The goal was to see if the drug is safe and how it affects certain proteins in the body. The trial was open-lab…

This study tested an online tool called WeCareAdvisor that helps caregivers of people with dementia manage behavioral and psychological symptoms. 262 caregivers used the tool for 6 months, with some receiving extra prompts. The goal was to see if it reduces caregiver distress and…

This study tested a dementia care program delivered by phone and web, where trained navigators helped patients and caregivers manage care. Over 1,200 people with dementia and their caregivers took part across six health systems. The goal was to see if this approach could improve …

This study tested a video-based program called STELLA-FTD to help family caregivers of people with frontotemporal dementia (FTD). Sixteen caregivers participated in the program, which aimed to reduce their stress and improve their quality of life. The approach used videoconferenc…

This pilot study tested whether wearable sensors can measure apathy in people with frontotemporal dementia and healthy volunteers. Researchers used video recordings and motion sensors to track behaviors like lying, sitting, and energy use. The goal was to see if this technology c…

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia recall personal memories. Researchers analyzed whether memories were specific events or more general. The goal was to better understand memory changes in these conditions, not to test a …

This study interviewed 26 adults who either have behavioral variant frontotemporal dementia (bvFTD) or carry a gene that puts them at risk. The goal was to learn how the condition affects daily life, emotions, and coping. No treatment or medication was tested—just listening and g…

This study examined over 2,200 people with frontotemporal dementia (FTD) or symptoms of it to find out how many cases are linked to specific genes. Researchers collected genetic samples to better understand the causes of this rare brain disease. The goal was to gather knowledge, …

This study looked at how the prefrontal cortex helps us think in analogies and categories. Researchers tested healthy volunteers and patients with frontotemporal dementia or progressive supranuclear palsy using tasks that measure reaction time and accuracy. They also used brain s…

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …