Experimental drug tested in people carrying dementia genes

NCT ID NCT03987295

Completed Disease control Sponsor: Alector Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested the safety and effects of an experimental drug called AL001 in people who carry genetic mutations that cause frontotemporal dementia. The drug was given intravenously to 33 participants over nearly two years to see how their bodies handled it and to measure certain biological markers. The main goal was to understand if the treatment was safe and tolerable, not to cure the disease.

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Contacts and locations

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Locations

Brain Research Center - PPDS

Amsterdam, 1081GN, Netherlands
Erasmus University Medical Center

Rotterdam, 3015 GD, Netherlands
Lawson Health Research Institute, St. Joseph's

London, Ontario, N6A 4V2, Canada
Mayo Clinic

Rochester, Minnesota, 55905, United States
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Technical University of Munich

München, 81675, Germany
The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases UT Health San Antonio

San Antonio, Texas, 78229, United States
UCSF

San Francisco, California, 94158, United States
University College London

London, WC1N 3BG, United Kingdom
University of Brescia

Brescia, 25123, Italy
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Ulm

Ulm, 89081, Germany

Conditions

Explore the condition pages connected to this study.

FRONTOTEMPORAL DEMENTIA