EGFR

This is the first human study testing a new cancer drug called TT125-802 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check if the drug is safe and well-tolerated, while also looking for early signs that it might he…

This study is comparing a new daily pill called firmonertinib against standard platinum-based chemotherapy for people with advanced non-small cell lung cancer (NSCLC) who have specific genetic changes (EGFR PACC or L861Q mutations). The goal is to see if the pill is more effectiv…

This is the first study in people to test a new drug called EPI-326. It aims to find a safe dose and see how the body handles the drug in patients with advanced lung cancer (with a specific genetic change) or advanced head and neck cancer. The main goal is to check for side effec…

This study is testing whether switching to a special salt substitute can help protect kidney function in people who have had surgery to remove a kidney tumor. Researchers will compare patients using a potassium-enriched, low-sodium salt to those using regular table salt for one y…

This study is testing whether adding a new drug called zipalertinib to standard chemotherapy after lung cancer surgery works better than chemotherapy alone. It's for people with early-stage lung cancer who have specific, less common genetic changes in their tumor. The goal is to …

This is the first human study of a new experimental drug called VIR-5525 for people with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will test VIR-5525 alone and combined with an existing immunotherapy drug (pembrolizumab) in 450 participan…

This study is testing a two-step treatment for advanced non-small cell lung cancer in patients whose previous targeted therapy has stopped working. First, patients receive a short course of chemotherapy, then switch to a different targeted drug called befotertinib. The goal is to…