EGFR

This is the first-ever study in people to test a new cancer drug called TT125-802. The main goal is to find a safe dose and check for side effects in 50 adults with advanced solid tumors that have stopped responding to standard treatments. Researchers will also look for early sig…

This study compares a new targeted drug called firmonertinib against standard chemotherapy for people with advanced non-small cell lung cancer who have specific genetic changes (EGFR PACC or L861Q mutations). About 300 participants will be randomly assigned to receive either the …

This study is testing whether adding a new drug called zipalertinib to standard chemotherapy after lung cancer surgery works better than chemotherapy alone. It's for people with early-stage lung cancer who have specific, less common genetic changes in their tumor. The goal is to …

This is the first human study of a new experimental drug called VIR-5525 for people with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will test VIR-5525 alone and combined with an existing immunotherapy drug (pembrolizumab) in 450 participan…

This is the first-ever study in people for a new drug called EPI-326. It aims to find a safe dose and see how the body handles the drug in patients with advanced lung cancer (with a specific genetic change called EGFR mutation) or advanced head and neck cancer. The main goal is t…

This study is testing a two-step treatment for advanced non-small cell lung cancer in patients whose previous targeted therapy has stopped working. First, patients receive a short course of chemotherapy, then switch to a different targeted drug called befotertinib. The goal is to…

This study is testing whether using a potassium-enriched salt substitute instead of regular table salt can help protect kidney function in people who have had surgery to remove a kidney tumor. Researchers will follow 200 patients for one year, comparing those who use the special …