DYSPNEA

This study looks at whether emergency doctors can use a lung ultrasound in the ambulance to better diagnose why a patient is struggling to breathe. About 40 adults with severe shortness of breath will be included. The goal is to see if the ultrasound helps doctors choose the righ…

This study looks at whether measuring the difference between two types of CO2 levels (from a blood test and a skin sensor) can help emergency doctors figure out if a patient's shortness of breath is caused by fluid buildup in the lungs or something else. About 45 adults with sudd…

This study looks at whether using lung and heart ultrasound helps emergency doctors give the right treatment faster to older adults (over 65) who come to the ER with sudden breathing trouble. About 504 participants will be enrolled, and doctors trained in the ultrasound technique…

This study looks at whether a quick ultrasound of a large vein (the inferior vena cava) can help emergency doctors figure out why a patient is having sudden trouble breathing. The goal is to tell apart fluid in the lungs from heart problems versus other causes. Researchers will e…

This study tests a personalized treatment plan called SPOT-ON that combines oxygen therapy with other supportive care to reduce shortness of breath in cancer patients. Researchers will enroll 150 adults with cancer who are hospitalized and have significant breathing trouble. The …

This study tests two breathing exercises—segmental breathing and active cycle breathing—against standard care in 99 adults recovering from open heart surgery. The goal is to see which technique better reduces shortness of breath and improves oxygen levels, heart rate, and blood p…

This study tests if using a hand fan can prevent or reduce shortness of breath caused by the heart drug ticagrelor. About 110 adults with acute coronary syndrome will be enrolled. Researchers will track who gets breathing trouble and how soon it starts after taking the medication…

This study explores whether inhaling menthol can quickly relieve shortness of breath in healthy adults and people with COPD. Researchers will measure brain and breathing responses during exercise and breathing tests. The goal is to understand how menthol works, so it can be devel…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for 6 months, and n…

This study tests whether a simple breathing exercise using a small handheld device can strengthen breathing muscles and reduce shortness of breath in women receiving chemotherapy for early-stage breast cancer. About 58 participants will use the device regularly during treatment. …

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study tests whether starting a structured exercise and education program soon after a hospital stay for a pulmonary embolism (a blood clot in the lungs) can improve quality of life and reduce long-term symptoms like shortness of breath. About 160 high-risk adults will be ran…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension. Researchers want to understand if diaphragm problems are linked to shortness of breath. No new treatments are being tested—this is an observat…

This study looks at 50 adults who have shortness of breath. Researchers will use a simple breathing test called oscillometry to measure airway resistance. They want to see if these measurements relate to results from exercise tests. The goal is to better understand what causes br…

This study looks at why people with myasthenia gravis (MG) feel short of breath, even during rest or sleep. Researchers will use breathing tests, sleep studies, and questionnaires in 50 adults with MG to better understand the causes. The goal is to improve treatment and quality o…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to see if these images can help measure lung function in people with conditions like lung scarring, blood clots in the lungs,…