DYSPEPSIA

This study tests whether adding a probiotic (Saccharomyces boulardii) to a standard 4-drug antibiotic regimen helps clear H. pylori infection in people whose past treatment failed. About 1,248 adults will be randomly assigned to get either the probiotic plus antibiotics or antibi…

This study tests whether a newer drug (vonoprazan) works better than a standard drug (esomeprazole) when combined with two antibiotics to treat H. pylori infection. About 80 adults with stomach discomfort and confirmed H. pylori will take one of the two treatments for 14 days. Fo…

This study tests a simple, non-drug technique to reduce visible belly bloating in people with Irritable Bowel Syndrome (IBS) or indigestion. 100 adults who get visibly bloated after meals will be randomly assigned to learn special breathing exercises or take a placebo pill. The g…

This study tests whether domperidone can help control symptoms like nausea, vomiting, bloating, and heartburn in people with chronic stomach and digestive disorders. It is for patients who have not gotten better with standard treatments. The study measures symptom changes over 8 …

This study explores whether a mild electrical stimulation on the ear (called taVNS) can improve how the brain and stomach work together in people with functional dyspepsia (indigestion) or gastroparesis (slow stomach emptying). Researchers will use brain scans and stomach activit…

This study tests whether a drink made from Chios mastic, a natural resin, can help adults with dyspepsia (persistent stomach discomfort). 60 participants will drink either a mastic-enriched carbonated beverage or a placebo daily for 3 months. Researchers will track changes in sym…

This study tests a type of talking therapy (exposure-based CBT) for adults who have both functional dyspepsia (stomach pain or fullness after eating) and avoidant/restrictive food intake disorder (ARFID) with weight loss. The goal is to see if the therapy helps people eat more co…

This study is for adults who are already scheduled for a routine throat scope. Researchers want to see if having heterotopic gastric mucosa (HGM) — a patch of stomach-like tissue in the upper esophagus — is linked to trouble swallowing or indigestion. Participants fill out questi…

This study aims to collect medical information and biological samples (blood, urine, stool, and gut biopsies) from 2000 adults with functional digestive disorders like irritable bowel syndrome, indigestion, and constipation. The goal is to identify markers that could help diagnos…

This study measures the carbon footprint of upper GI endoscopy in patients with indigestion (dyspepsia) or stomach bleeding. Researchers will track emissions from the moment a patient enters the endoscopy room until they leave. The goal is to compare the environmental impact of d…