DRY EYE

This study tests a small device that attaches to a smartphone to help diagnose dry eye disease. It takes special pictures of the eye's surface using different lights. The goal is to see if people can use it at home to get accurate results, compared to a standard eye exam. About 5…

This study looks at whether switching from the dry eye drop Xiidra to a new drop called TRYPTYR (acoltremon 0.003%) can better improve symptoms and tear production. About 100 adults with chronic dry eye who still have symptoms on Xiidra will take part. Researchers will measure te…

This study will compare three different tear substitute eye drops to see which one works best for reducing discomfort after cataract surgery. 300 adults with cataracts will be observed after their surgery. The goal is to find which eye drop provides the most relief from dry eye s…

This study tests a prescription eye drop called lifitegrast (Xiidra) in 30 adults with dry eye disease. Researchers will use a special microscope to see if the drops reduce immune cells on the eye's surface over 12 weeks. The goal is to understand how the treatment works, not to …

This study tests a special VR headset (Lacrima VR) to see if it can safely improve dry eye symptoms in adults with dry eye disease and meibomian gland dysfunction. Twenty participants will be randomly assigned to get either the active VR treatment or a sham device with dimmer lig…

This study looks at whether switching from the eye drop Restasis to a new drop called TRYPTYR can better relieve dry eye symptoms. About 100 adults who have used Restasis for at least a month but are still unhappy with their dry eye will take part. Researchers will measure tear p…

This early-stage study tests a new eye ointment called RC017 in 24 healthy adults aged 18 to 55. The goal is to see if the ointment is safe and how the body processes it after one or several doses. This is a first step before testing it in people with dry eye disease.

This study tests whether adding sodium hyaluronate (a moisturizer found in artificial tears) to autologous serum eye drops provides better relief for people with moderate-to-severe dry eye disease. Each of the 20 participants will use the new mixture in one eye and the standard s…

This study follows up with people who previously took part in a Sjögren's syndrome study at the University of Pennsylvania. Researchers will collect samples like tears, saliva, and blood, and perform eye and mouth exams to track changes over time. The goal is to better understand…

This study looks at how blinking behavior is linked to the stability of the tear film in adults aged 18 to 65, with or without dry eye symptoms. Participants will answer a questionnaire, have their vision checked, and undergo non-invasive tear film tests while performing blink ta…