Diabetic peripheral neuropathy

This small study tested whether injecting a person's own fat-derived cells (called stromal vascular fraction) into the foot could help heal diabetic nerve damage and foot ulcers. Eight adults with diabetic peripheral neuropathy received injections around the wound and along nerve…

Researchers are testing whether a two-week course of functional magnetic stimulation applied to the sole of the foot can improve feeling, foot strength, balance, and walking in adults with type 2 diabetes and diabetic peripheral neuropathy. Participants are randomly assigned to r…

This study tests two different exercise programs in 40 people with diabetic peripheral neuropathy, a condition that causes numbness and balance problems. One program uses Feldenkrais exercises, which focus on movement awareness, and the other uses task-oriented gait training, whi…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

This phase 2 trial tests whether mazisotine, an oral drug, can reduce the persistent nerve pain that often complicates diabetes. About 400 adults with diabetic peripheral neuropathic pain will receive either mazisotine or a placebo for roughly 24 weeks. Researchers will measure c…

This trial tests whether a non-invasive device that delivers pulsed radiofrequency energy behind the knee can reduce pain and improve function in people with diabetic neuropathy whose pain persists despite medication. About 92 participants will receive either the active device or…

This study tests whether special balance exercises or sensory retraining better improve walking and stability in people with diabetic nerve damage. 80 adults aged 40-75 with diabetes and nerve problems will be randomly assigned to one of two training programs. Both groups also re…

This study tested two non-invasive treatments—low-level laser and transcutaneous vagus nerve stimulation—in 30 adults with diabetic neuropathy. The goal was to see which better improves blood flow and reduces nerve pain. Participants had diabetes for over 5 years and stable blood…

This pilot study tested whether a structured foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life, compared to walking or standard care. Over 12 weeks, 108 participants either did foot-ankle exercises, walked regularly,…

This study tested whether a gene therapy called engensis can safely reduce pain from diabetic nerve damage over 6 to 12 months. About 100 people who completed an earlier trial received either engensis or placebo injections into their leg muscles. Researchers measured changes in d…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…