DEPRESSION IN ADULTS

This study looks at whether treating depression with an online therapy program can improve how the body uses insulin in people with HIV who are on HIV medication. About 150 adults with HIV and depression will either receive 9 weeks of internet-based cognitive behavioral therapy o…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests whether heated yoga or sauna sessions, combined with a mindfulness app, can help reduce symptoms of depression. Researchers will enroll 120 adults aged 18 to 65 who have at least moderate depression. Participants will be assigned to one of the two heat-based acti…

This study tests whether personalized music playlists can lower stress, anxiety, and depression in adults. 2000 participants will be randomly assigned to either listen to custom playlists or receive no music intervention. The goal is to see if music can be a simple, non-drug tool…

This study tests whether a new drug, CYB003, can safely and effectively reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 330 participants will receive either one of two doses of CYB003 or a placebo, added to their current antidepressan…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study is testing a type of talk therapy called acceptance and commitment therapy (ACT) for people with mild dementia and their care partners. The goal is to see if the therapy is practical and helpful for reducing symptoms like depression, anxiety, and grief. About 100 pairs…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method works better at getting patients to start a telehealth program that offers counseling and support. About 30 adults being treat…

This small pilot study is testing whether a brief, culturally adapted form of behavioral activation therapy is acceptable and practical for adults with depression in a primary care setting. Researchers will work with 12 participants and their healthcare providers to see if the th…