DEPRESSION DISORDERS

This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help control tumors better in people with advanced liver or gallbladder cancer who also have depression or anxiety. About 240 participants will be randomly assigned to receive imm…

This study tests whether heated yoga or sauna sessions, combined with a mindfulness app, can help reduce symptoms of depression. Researchers will enroll 120 adults aged 18 to 65 who have at least moderate depression. Participants will be assigned to one of the two heat-based acti…

This study tests whether a new drug, CYB003, can safely and effectively reduce depression symptoms in adults with moderate-to-severe major depressive disorder. About 330 participants will receive either one of two doses of CYB003 or a placebo, added to their current antidepressan…

This study tests whether an online recovery education and support program, led by trained teen peers and support specialists, can help teens aged 15-18 who were recently hospitalized for suicidal thoughts, depression, or anxiety. Participants are split into two groups: one gets t…

This study tests whether a non-invasive brain stimulation method called tACS can improve impulse control and reduce self-injury in 60 adolescents aged 12-18 with non-suicidal self-injury (NSSI). Participants receive either real or sham stimulation twice daily for 7 days. Research…

This study tests a meditation-based brain-training method to help people with moderate depression. 27 adults will learn to control their brain activity using real-time feedback while meditating. The goal is to see if this approach can reduce depression symptoms without medication…

This study tests a group mental health program delivered by phone or video for adults 55 and older who feel lonely, isolated, or have anxiety or depression. About 128 participants across four Canadian provinces will either join the program or continue their usual community activi…

This study aims to identify subgroups of people with diabetes who share similar patterns in how their blood sugar and mental health (like distress, anxiety, or eating disorders) are linked. Over 1,800 participants will use smartphone surveys and continuous glucose monitors for tw…

This study tests whether adding patients' own goals and concerns to their mental health care plan helps them stay engaged in treatment. About 2,400 adults receiving collaborative care for anxiety or depression will use an enhanced questionnaire and dashboard. Researchers will com…

This study will closely examine the physical and mental health of 100 adults admitted to NHS psychiatric wards. Researchers want to learn how common physical illnesses are in this group and how severe their mental health symptoms are. The goal is to better understand the overall …

This study explores the link between mental health and symptom severity in 200 adults with graft-versus-host disease (GvHD), a complication after bone marrow transplant. Researchers will use questionnaires to measure depression, anxiety, and quality of life. The goal is to see if…

This study looks at how common depression is among healthcare workers in heart and lung surgery departments in Baghdad. About 200 doctors, nurses, and support staff will fill out a simple questionnaire about their mood. The goal is to understand how many are affected and what fac…

This study tests whether an AI tool can reliably measure depression and anxiety severity by analyzing video interviews. About 120 adults with depression or anxiety will complete online questionnaires and talk to both an AI interviewer and human clinicians. The goal is to see if A…

This study is testing a device called Gaize to see if it can detect changes in eye movements caused by long-term use of psychiatric medications like those for ADHD, depression, or anxiety. Researchers will use standard drug recognition tests in a virtual setting. The goal is to u…

This study is testing whether a new web-based AI platform called Okaya can accurately detect fatigue and depression in people with heart conditions. Researchers will compare the platform's results to standard questionnaires (PHQ-9 and FAS). About 100 adults who speak English and …