CYSTIC FIBROSIS

This pilot study tests whether the diabetes drug empagliflozin is safe and tolerable for overweight or obese adults with cystic fibrosis-related diabetes (CFRD). Eight participants will receive either the drug or a placebo, then switch after a break. The goal is to gather early d…

This study tests the long-term safety and effectiveness of a triple-combination drug (VX-121/TEZ/D-IVA) in people with cystic fibrosis. About 822 participants who completed earlier studies will take the medication and be monitored for side effects, lung function, and other health…

This study tests a new drug called VX-522 in adults with cystic fibrosis whose genetic mutations do not respond to existing CFTR modulator therapies. The main goals are to check if the drug is safe and tolerable, and to see if it improves lung function. About 26 participants aged…

This study looks at the long-term safety and effectiveness of a triple combination drug (vanzacaftor/tezacaftor/deutivacaftor) for people with cystic fibrosis aged 1 year and older. Participants who completed a previous study are invited to join. The goal is to see if the drug is…

This study looks at the long-term safety and how well the body handles a drug combination (elexacaftor/tezacaftor/ivacaftor, also known as Trikafta) in people with cystic fibrosis who are 12 months old or older. About 50 participants who completed a previous study will continue t…

This study looks at the long-term safety and effectiveness of the drug combination Trikafta (elexacaftor/tezacaftor/ivacaftor) in about 300 people with cystic fibrosis who have certain gene changes. Participants take the medication and are monitored for side effects, lung functio…

This study compares two non-invasive stool tests (DNA and FIT) to standard colonoscopy for detecting colorectal cancer and precancerous growths in 350 adults with cystic fibrosis. The goal is to see if these simpler tests can accurately identify cancer or polyps, potentially redu…

This study looks at whether a bronchodilator (a drug that opens airways) can reduce shortness of breath and improve exercise ability in adults with cystic fibrosis. About 20 participants will receive either the drug or a placebo and then switch, so each person acts as their own c…

This study looks at whether a strength exercise program can improve muscle health in children and teens with cystic fibrosis who are taking new CFTR modulator drugs. 48 participants will be randomly assigned to either an exercise group or a control group. Researchers will measure…

This study follows 285 pregnant women with cystic fibrosis who are taking highly effective CFTR modulators. Researchers measure lung function before, during, and up to two years after pregnancy to see how pregnancy affects breathing. The goal is to better understand maternal and …

This study follows 5 people with cystic fibrosis who previously received a single dose of BI 3720931 gene therapy or placebo. No new treatment is given. Researchers will check for long-term side effects and track lung function over up to 15 years to see if the therapy remains eff…

This study looks at how different types of Achromobacter bacteria affect the lungs of people with cystic fibrosis. Researchers in Réunion Island will follow 17 patients to see if certain bacteria cause more lung flare-ups or lead to long-term infection. The goal is to better unde…

This study looks at how nontuberculous mycobacteria (NTM) — hard-to-treat lung infections — spread among people with cystic fibrosis. Researchers will collect dust and water samples from clinics and patients' homes to find possible sources. The goal is to better understand transm…

This study looks at how muscle strength, body composition, and nutrition relate to lung function in 300 adults with cystic fibrosis. Researchers will compare simple tests like grip strength and walking distance to a standard body scan. The goal is to find better ways to track and…

This study looks at the genes of 600 people with cystic fibrosis to find out why some have more severe lung disease than others. It does not test any new treatment. Instead, it collects genetic information to help researchers understand the disease better. Participants must have …

This study follows 70 infants with cystic fibrosis to see if a specific bacteria in the mouth at 12 months old can predict a serious lung infection at 36 months. Researchers collect spit and stool samples over time. The goal is to find early warning signs, not to test a treatment…

This study looks at 5,000 people with cystic fibrosis who are already taking approved CFTR modulator drugs. Researchers want to see how these medicines change sweat chloride levels and if those changes relate to better health. The goal is to learn more about how well the drugs wo…

This study looks at how small blood vessels in the lungs change in people with cystic fibrosis (CF). Researchers will use special scans to measure blood vessel loss and see how it relates to lung function. The goal is to better understand CF lung disease, not to test a new treatm…

This study tests whether a special type of MRI, using a harmless inhaled gas, can detect early lung function changes in people with cystic fibrosis who are starting a new triple-combination therapy. About 64 participants will be scanned before and after starting treatment, and ag…

This study explores why some people with cystic fibrosis develop severe liver disease while others do not. Researchers are analyzing blood samples and medical records from 154 participants to find 'modifier genes' that may influence liver disease severity. The goal is to better u…

This study tests if a special website helps people with cystic fibrosis (CF) feel more prepared to discuss lung transplant with their doctors. Many people with CF die without ever considering this option, especially those from marginalized communities. Over 6 months, 132 particip…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study uses a new, contrast-free MRI technique to measure blood flow in the lungs of 26 children with cystic fibrosis (CF) and compare it to healthy controls. The goal is to see if blood flow problems occur before or alongside the more commonly measured airway damage. By trac…

This study was designed to see if a special breathing technique called autogenic drainage could improve how air moves through the lungs of people with cystic fibrosis. The researchers planned to measure lung function before, right after, and two hours after the technique. However…

This study looks at how CFTR modulators, a type of cystic fibrosis treatment, affect bone strength and muscle mass in adults with CF. Researchers will measure changes in bone density and lean body mass over 12 to 24 months. The goal is to understand whether these treatments help …

This study tests a new, tiny camera (micro OCT) that can take detailed pictures of the airways in the lungs and nose. Researchers want to see if it works well in adults with cystic fibrosis and healthy volunteers. The goal is to better understand early lung damage, which could le…