CHRONIC MYELOID LEUKEMIA

This study tests a new daily pill, TERN-701, for adults with chronic myeloid leukemia (CML) whose cancer has not responded well to or caused side effects from other treatments. The trial has two parts: first finding the safest dose, then testing that dose in more people to see ho…

This early-stage study tests a new drug, CBX-250, in people with certain types of blood cancers (myeloid leukemias) that have returned or not responded to standard treatments. The main goals are to find a safe dose and see how well people tolerate the drug. About 72 participants …

This study tests a drug called olverembatinib in 50 adults newly diagnosed with chronic myeloid leukemia (CML) in its early phase. The goal is to see if the drug can control the cancer and what side effects it may cause. Participants take the drug alone, without other treatments,…

This early-stage study tests a new drug called ELVN-001 in about 250 adults with chronic myeloid leukemia (CML) whose cancer has stopped responding to or who cannot tolerate other treatments. The main goals are to check the drug's safety and find the best dose. Participants will …

This early-phase study tests a combination of two drugs—selumetinib and azacitidine—in adults with higher-risk blood cancers like myelodysplastic syndromes (MDS) and myelofibrosis. The main goal is to find the safest dose of selumetinib when given with standard azacitidine. Up to…

This study tests an experimental pill called HQP1351 in adults with chronic myeloid leukemia (CML) or a related blood cancer (Ph+ ALL) that has stopped responding to at least two standard treatments. The goal is to find the best dose and check how safe and effective the drug is. …

This study tests whether the drug asciminib can help control chronic myeloid leukemia (CML) in people who were recently diagnosed. About 50 adults will take the drug, and researchers will watch for side effects and how well the drug works. The goal is to manage the disease, not t…

This early-stage trial tests a new drug called MGD024 in people with certain blood cancers (like leukemia and lymphoma) that came back or didn't get better with standard treatments. The main goal is to find a safe dose and understand side effects. About 130 adults will receive th…

This study tests a new combination of drugs (bendamustine and cyclophosphamide) to prevent graft-versus-host disease and a dangerous immune reaction after a stem cell transplant. It includes 60 adults with high-risk blood cancers like acute myeloid leukemia or myelodysplastic syn…

This study is for people with certain blood cancers (like leukemia) who are getting a half-matched bone marrow transplant. Researchers are adding a dose of specially grown immune cells (gamma delta T-cells) after the transplant to see if it can kill any leftover cancer cells whil…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This early-phase trial tests a new treatment for children and adults with acute leukemia that has come back or not responded after a donor stem cell transplant. The treatment uses specially engineered immune cells (T cells) from the original donor that are trained to recognize an…

This study is observing 600 Korean adults with chronic myeloid leukemia who are taking Scemblix (asciminib) as part of their regular care. Researchers will track side effects and how well the drug controls the disease over time. The goal is to see how the medicine performs outsid…

This study looks at whether a person's personality traits are linked to how consistently they take their daily cancer medication for chronic myeloid leukemia (CML). Researchers will ask 75 adults with CML to fill out questionnaires about their personality, medication habits, and …

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of mu…