CHRONIC LOW-BACK PAIN (CLBP)

This study tests a treatment called JHG002 for people with chronic low back pain lasting 6 months or more. About 96 adults aged 19 to 69 with moderate to severe pain will receive JHG002 or a comparison treatment. The main goal is to see if pain levels drop over 6 weeks.

This study tests a new way to stimulate muscles through the spinal cord to treat chronic low back pain. Researchers will enroll 30 adults who already have a spinal cord stimulator and get good pain relief from it. The goal is to see if this new method can further reduce pain and …

This study looks at whether adding Osteopathic Manipulative Therapy (OMT) — a hands-on technique using stretching and gentle pressure — to standard VA care can improve outcomes for veterans and service members with chronic low back pain. About 48 participants will be randomly ass…

This study tests a once-weekly injection called retatrutide to see if it can relieve chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The main goals are t…

This study tests whether adding a meditation program or pain education to standard sleep therapy (CBT for insomnia) can better reduce pain in adults with chronic low back pain and insomnia. About 300 participants will be assigned to one of these add-on treatments. The goal is to …

This small pilot study is testing whether osteopathic manipulative treatment (OMT) on the legs and feet can reduce chronic low back pain and improve daily function. Twenty adults with long-term back pain will receive four OMT sessions over several weeks. Researchers will measure …

This study tests whether adding a non-invasive brain stimulation technique (rTMS) to a special type of physiotherapy can better relieve chronic low back pain in military veterans. The approach targets both physical and emotional aspects of pain. Researchers will measure changes i…

This study tests whether combining acceptance and commitment therapy (a mindfulness-based approach) with exercise classes can reduce pain and disability in older adults with chronic low-back pain. About 100 people aged 60 and older will take part in community centers. The goal is…

This study looks at whether a single session of isometric exercise (holding a muscle contraction without moving) can immediately reduce pain sensitivity and pain intensity in adults with chronic low back pain. About 90 participants will be randomly assigned to exercise or a contr…

This study tests a brief behavioral treatment delivered over Zoom for adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to help participants learn strategies to reduce pain, disability, and related issues like depression or anxiety. About…

This study tests if adding active movement to passive hamstring stretches improves flexibility more than passive stretching alone in people with chronic low back pain. About 90 adults aged 18-65 with long-term back pain and tight hamstrings will be randomly assigned to one of two…

This study tests whether a procedure called lumbar radiofrequency ablation (LRFA) can reduce disability from chronic low back pain better than a pretend procedure. About 300 adults with pain lasting at least 3 months will be randomly assigned to one of two types of LRFA or a sham…

This study tests whether a special hands-on therapy called Pelvic External Myofascial Mobilisation (PEMM) combined with strengthening exercises can help women who have both chronic low back pain and urinary incontinence. About 130 women aged 18–65 with these conditions will be ra…

This study looks at whether lumbar stabilization exercises or back endurance exercises are better at improving spine movement and stability in female university students with chronic low back pain. About 60 participants will be assigned to one of the two exercise groups. The goal…

This study compares two treatments for chronic low back pain: routine physical therapy and a biopsychosocial approach that adds hands-on therapy, education, and mental strategies. Researchers will measure pain, disability, and social support in 80 adults with back pain lasting ov…

This study tests whether a special ultrasound test (called the NUN biomarker) can track changes in chronic low back pain after dry needling and predict who will benefit most. Researchers will compare real dry needling to a sham (fake) version in 80 adults with muscle-related back…

This study looks at how a 12-week online exercise program changes the brain and immune system in people with chronic low back pain. Researchers will compare participants who exercise with those on a waitlist, and also compare them to healthy volunteers. The goal is to understand …

This study looks at how chronic sleep problems and pain sensitivity affect each other in people with long-term low back pain and insomnia. Researchers will use brain scans to measure chemicals and brain activity in 80 adults aged 18-60. The goal is to better understand the link b…

This study looks at how dry needling works to relieve chronic low back pain. Researchers will study 71 adults aged 18-65 who have had low back pain for at least 3 months. Participants will receive dry needling and complete surveys and tests to measure pain, muscle stiffness, and …