CHRONIC HEART FAILURE

This study looks at whether a special type of pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after having their aortic valve replaced. About 360 adults who had a successful valve replacement and now have a n…

This study looks at whether the drug vericiguat can improve heart function in adults with stable heart failure with reduced ejection fraction (HFrEF). About 60 participants will either take vericiguat plus their usual medications or just their usual medications. Researchers will …

This study tests a temporary heart pump (iVAC 2L) in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps keep blood flowing during the procedure, which may reduce the chance of death, heart attack, or stroke. The goal is to see if the dev…

This study tests a device that automatically tracks leg swelling in people with heart failure. The goal is to catch worsening symptoms early and reduce hospital visits. About 1,500 adults with chronic heart failure and a history of leg swelling will use the device at home for at …

This study tests whether replacing the gut bacteria of people with chronic heart failure with bacteria from healthy donors is safe and possible. About 40 adults with stable heart failure will take capsules containing donor bacteria. The goal is to see if this approach can improve…

This study is testing whether a special wearable device, guided by artificial intelligence, can help adults with chronic heart failure avoid emergency visits and hospital stays. About 205 participants will either wear the device for six months or receive standard care. The goal i…

This study tests whether injecting stem cells from donated umbilical cords into the heart muscle, during bypass surgery, can help people with chronic heart failure caused by blocked arteries. About 51 adults with weak hearts (ejection fraction 40% or less) will take part. The goa…

This study looks at whether giving iron through a vein (Ferinject®) can improve quality of life and physical function in people with a type of heart failure called HFpEF who also have low iron stores. About 100 hospitalized adults will be randomly assigned to receive either the i…

This study tests whether an 8-week machine-based resistance training program can improve muscle strength and physical function in older adults (60+) who have both chronic heart failure and sarcopenia (age-related muscle loss). About 146 participants will be randomly assigned to e…

This study looks at whether combining physical exercise with cognitive training (like brain games) can improve memory, thinking speed, and overall brain health in people aged 50 and older with stable chronic heart failure. Researchers will also check if the benefits differ betwee…

This study looks at whether low or high volume high-intensity interval training (HIIT) is better for people with chronic heart failure. It aims to improve how well they can exercise and their quality of life. About 45 adults with stable heart failure and reduced pumping ability w…

This study tests whether regular yoga practice can improve quality of life and reduce anxiety and depression in people with stable chronic heart failure. About 66 adults with heart failure will be randomly assigned to add yoga to their usual care or continue usual care alone. The…

This study tests whether a special oral iron supplement (sucrosomial iron) can improve exercise ability and quality of life in people with chronic heart failure who also have low iron levels. About 60 participants will receive either the iron supplement or a placebo for several w…

This study looks at how two breathing treatments—high-flow oxygen therapy and non-invasive ventilation—affect heart function in people with chronic heart failure. Researchers want to see if high-flow oxygen can lower pressure in the heart's blood vessels. The study involves 30 ad…

This study will collect information from 20,000 people with chronic heart failure across Russia. Researchers want to understand how the disease is found, treated, and followed over time. No new treatments are tested—the goal is to learn what is actually happening in clinics to im…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 adults over age 50 with type 2 diabetes, but no history of heart problems. They will use blood tests and heart ultrasoun…

This study looks at the safety of finerenone, a drug already approved for chronic heart failure, in 300 adults in South Korea. Participants take the drug as prescribed by their doctor, and researchers collect data from routine care for one year. The goal is to see how safe and ef…

This study follows 1400 Japanese people with chronic heart failure who are prescribed vericiguat by their doctors. Researchers will track side effects and heart-related deaths over two years to see how safe the drug is in real-world use. Participants continue their normal treatme…