Blood markers may predict kidney failure in heart patients
NCT ID NCT07139626
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether certain proteins in the blood can predict if someone with chronic heart failure will develop kidney problems (cardiorenal syndrome). Researchers will measure these proteins in 150 adults with heart failure and follow them for one year. The goal is to find a simple blood test that gives an early warning, so doctors can step in sooner.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be recruited from chronic heart failure (CHF) patients attending the cardiology outpatient clinics or admitted to the cardiology wards of a tertiary care hospital in China. The study focuses on adults with stable CHF(HFrEF, HFmrEF, HFpEF). The hospital is a regional referral center with a high volume of HF cases, ensuring a diverse and representative sample. Eligible patients will be enrolled based on clinical diagnosis and willingness to participate in biomarker analysis and follow-up assessments.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 to 75 years. * Diagnosed with stable chronic heart failure (HF) according to the 2024 Chinese Heart Failure Diagnosis and Treatment Guideline. * HF subtypes include: HFrEF (LVEF ≤40%), HFmrEF (LVEF 41 - 49%), HFpEF (LVEF ≥50%). * Willing to provide blood samples for biomarker analysis. * Able to comply with follow - up visits and study procedures for 12 months. * Note: For the screening phase, 10 patients will be included for each subtype; for the validation phase, 30 patients will be included for each subtype. Exclusion Criteria: * History of long-term dialysis or kidney surgery. * Acute kidney injury (AKI) within the past 3 months. * Use of nephrotoxic drugs within the past 3 months. * Diagnosis of autoimmune diseases (e.g., lupus, rheumatoid arthritis). * Active malignancy or history of cancer treatment within the past 5 years. * Acute infectious diseases at the time of enrollment. * Severe liver dysfunction (e.g., cirrhosis, ALT/AST \>3× upper limit of normal). * Pregnancy or lactation. * Inability or unwillingness to provide informed consent. * Participation in another interventional clinical trial within the past 30 days.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Affiliated Hospital of Nantong University
RECRUITINGNantong, Jiangsu, China
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