CHONDROSARCOMA

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will take …

This study tests a new way to deliver proton therapy for people with chordoma or chondrosarcoma at the base of the skull. Instead of many small doses, patients receive 5 high-precision treatments. The goal is to see if this approach controls tumor growth while reducing side effec…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (cancers like chordoma or osteosarcoma). The goal is to see which treatment provides better quality of life and disease control with fewer side effects. About 72 participants …

This study is for people with bone sarcomas who have finished their first round of treatment. It tests whether taking the drug regorafenib for up to 12 months can help keep the cancer from returning, compared to just being watched. About 168 participants will be randomly assigned…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function returns over 3 years. The goal is to learn more about recovery after these…

This study looks at how well people with bone cancer follow a personalized home exercise program after having surgery to remove a tumor from their leg. About 50 patients will track their daily exercises for six months. The goal is to understand what helps or hinders them from sti…

This early-phase study tests whether a new radioactive tracer can help doctors see tumors on PET/CT scans. About 32 adults with different solid tumors will receive a single injection of the tracer. The goal is to understand where the tracer goes in the body, how it is cleared, an…

This study looks at whether using 3D printed models of a patient's bones helps surgeons plan and perform tumor removal surgery. About 150 people with bone tumors will be randomly assigned to have their surgeon use either 3D models plus regular scans, or just scans alone. The main…