CARDIOMYOPATHY

This study is testing whether stem cells from a donor's bone marrow can help control heart failure in people whose hearts were weakened by certain chemotherapy drugs. Researchers will compare two different ways of giving the cells (through an IV or directly into the heart) agains…

This study is testing whether an 8-week exercise program done at home or in the community can improve fitness and quality of life for adults with reduced heart or lung function. Researchers will compare 200 participants who do the exercise program to those who do not. The program…

This study aims to find out which of two commonly used heart failure medications works better for patients who also have an implanted defibrillator. It will follow 2,000 participants for up to 3 years to see which drug leads to fewer defibrillator shocks, fewer hospital visits, a…

This study is testing a new, paddle-shaped catheter designed to create detailed maps of irregular heartbeats. Doctors will use it on 60 patients with conditions like atrial fibrillation or ventricular tachycardia to see if it's safe and works well. The goal is to see if this tool…

This study aims to better understand how a rare protein called amyloid damages the heart in people with a condition called light chain amyloidosis. Researchers will use advanced heart scans and blood tests to see how the protein affects the heart and if chemotherapy helps. The go…

This study aims to understand why some breast cancer patients develop heart problems after certain chemotherapy drugs. Researchers will collect blood samples from 200 patients to look for a specific marker (TRPC6) that might predict this risk. The goal is to learn how to identify…

This is an early, Phase 1 study to understand how a new potential heart medication called HRS-1893 behaves in the body. It will test two different pill versions and see if taking the pill with food changes how it's absorbed. The study involves 38 healthy adults and will closely m…

This study aims to understand how heart disease develops in people with Friedreich Ataxia, a rare genetic disorder. Researchers will follow 65 participants over time to track changes in heart structure and function. The goal is to gather detailed information that could help desig…

This study aims to learn more about rare and poorly understood diseases that affect the heart and blood vessels. Researchers will enroll up to 5,000 people, including patients, their relatives, and healthy volunteers, to collect medical data, images, and samples. The goal is to i…

This study aims to find the specific genes that cause inherited heart and muscle diseases like cardiomyopathy and muscular dystrophy. Researchers will analyze DNA from up to 2,000 patients and their family members who have these conditions. The goal is to better understand the ge…