CARDIOMYOPATHY

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal is…

This early-stage trial tests whether donor bone marrow stem cells can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with reduced heart function will receive either standard care alone or standard c…

This study tests artificial intelligence (AI) tools that help doctors interpret heart ultrasound images more accurately and quickly. The goal is to see if AI can speed up the diagnosis of conditions like genetic heart muscle disease, blocked arteries, and cardiac amyloidosis. Up …

This study tests whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will do 40-60 minutes of exercise (like brisk walking or cycling) five times a week for eight weeks. Researchers wi…

This study aims to find the genes that cause inherited heart and muscle diseases, such as cardiomyopathy, arrhythmia, and muscular dystrophy. Researchers will analyze DNA from patients and their families to identify mutations. The goal is to better understand these conditions, no…

This study tests whether two different versions of HRS-1893 tablets are processed the same way in the body. It involves 36 healthy adults aged 18 to 55. The goal is to measure drug levels in the blood, not to treat any disease.

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect blood, tissue, and perform imaging tests like MRI and CT scans. The goal is to improve diagnosis and understanding of these conditions. P…

This study looks at how different types of gene changes in the DMD gene are linked to heart problems in boys and young men (ages 2-24) with Duchenne or Becker muscular dystrophy. Researchers will use heart tests and blood samples to find early signs of heart issues. The goal is t…

This study involves 171 people with light chain amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers will use special PET and MRI scans to track these deposits and understand how they cause heart problems. The goal is not to treat the disease dir…

This study aims to learn more about how heart disease develops and changes over time in people with Friedreich ataxia, a rare genetic disorder. Researchers will monitor 65 participants aged 6 and older using heart imaging to track key measures like heart muscle thickness and mass…

This study is testing a new, paddle-shaped catheter designed to map abnormal heart rhythms (arrhythmias) in people with conditions like atrial fibrillation or ventricular tachycardia. About 60 participants will undergo a standard heart-mapping procedure using this investigational…

This study is looking at a protein called TRPC6 in the blood to see if it can predict which breast cancer patients will develop heart problems from chemotherapy. Researchers will collect blood samples from 200 patients to study genetic changes linked to heart damage. The goal is …