CANNABIS

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor called glioblastoma live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned…

This study tests whether dronabinol, a synthetic THC (the active compound in cannabis), can reduce severe breathlessness in people with advanced COPD. About 30 adults with very severe COPD who still struggle to breathe despite standard treatments will receive either dronabinol or…

This study tests whether a cannabis extract containing THC and CBD can reduce sudden nerve-related back pain and the need for strong painkillers. About 200 adults with acute radicular pain will receive either cannabis oil or a placebo, and researchers will track their pain levels…

This study looks at how two cannabis compounds, CBD and THC, affect inflammation and brain health in people with HIV. About 90 participants will take both compounds in a random order over 6 weeks. Researchers will measure blood markers and brain changes to better understand how c…

This study aims to understand how natural fluctuations in female sex hormones during the menstrual cycle influence the effects of cannabis. Researchers will measure subjective drug effects, cognitive performance, and craving in 21 women who use cannabis occasionally. Participants…

This study looks at whether cannabidiol (CBD) can reduce the psychoactive effects of tetrahydrocannabinol (THC) in healthy adults who use cannabis occasionally. Researchers will give participants different combinations of CBD and THC and measure how they feel and behave. The goal…

This study looks at how taking CBD repeatedly changes the way people respond to cannabis, including how much they like it and how it affects pain. Healthy adults aged 18-55 who are not seeking treatment for cannabis use can join. Researchers will measure drug liking and how much …

This study looks at how the active ingredient in cannabis, THC, affects women compared to men. Researchers want to understand differences in the feeling of being "high" and in memory. The study is for healthy adults who have used cannabis at least once. It does not offer treatmen…

This study looks at how long-term marijuana use affects brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure changes in brain health. The goal is to understand the effects, not to test a new treatment. About 220…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 regular users who smoke or vape both substances. The goal is to understand the combined health risks and inform public health gu…

This study looks at how cannabis affects driving in young (19-25) and middle-aged (35-45) adults. Half of the 128 participants will be occasional users, half frequent users. They will use a driving simulator to measure weaving and speed changes after cannabis use.