Women's hormones may change how cannabis feels
NCT ID NCT07417059
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how natural changes in female sex hormones during the menstrual cycle affect the way women feel and think after using cannabis. Researchers will give 21 women a set dose of THC (the active part of cannabis) or a placebo at different points in their cycle. They will measure mood, thinking, and physical responses to see if hormone levels make a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cannabis (THC)
- What this could lead to
- If successful, this could help explain why women respond differently to cannabis at different times of their menstrual cycle.
- What could go wrong
- This is a very small, early-stage observational study with only 21 participants, so results may not apply to all women. It is not testing a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 21 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Biological female * Used cannabis between 1 time a month and 2 times a week during the previous year * Age between 18 and 40 years * Free from psychotropic medication * Free from hormonal birth control * A regular menstrual cycle (last 3 cycles a duration between 21 and 35 days). * Good physical health as determined by medical examination and laboratory analysis * Absence of any major medical, endocrine and neurological condition as determined by medical examination and laboratory analysis * Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2 * Written Informed Consent * Good knowledge and understanding of the English language * Participants must be willing to refrain from taking illicit psychoactive substances during the study. * Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drinks after midnight of the evening before the study session, as well as during the study day. * Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. Exclusion Criteria: * History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) * Pregnancy or lactation or pregnancy planned during study participation * Hypertension (diastolic \> 90 mmHg; systolic \> 140 mmHg) * Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) * Current presence or history of psychosis in first-degree relatives * Any chronic or acute medical condition * History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…) * Tobacco smoking (\>20 per day) * Excessive drinking (\>20 alcoholic consumptions per week)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Maastricht University
RECRUITINGMaastricht, Netherlands
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