BRCA MUTATION
Clinical trials for BRCA MUTATION explained in plain language.
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New combo pill aims to shrink tumors in patients with BRCA and related gene mutations
Disease control Recruiting nowThis early-phase study tests whether combining two oral drugs, olaparib and ASTX727, can safely shrink advanced solid tumors in adults with inherited or acquired mutations in BRCA1, BRCA2, PALB2, ATM, or CHEK2 genes. About 18 participants will receive the combination to find the …
Matched conditions: BRCA MUTATION
Phase: PHASE1 • Sponsor: Pamela Munster • Aim: Disease control
Last updated May 26, 2026 03:52 UTC
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New drug targets Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…
Matched conditions: BRCA MUTATION
Phase: PHASE1, PHASE2 • Sponsor: 858 Therapeutics, Inc. • Aim: Disease control
Last updated May 19, 2026 11:48 UTC
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New scan could spot hidden prostate cancer spread in men with gene mutations
Diagnosis Recruiting nowThis study aims to see if a type of PET-CT scan (FCH-PET-CT) is better than standard scans (bone scan and MRI/CT) at finding cancer that has spread outside the pelvis in men with prostate cancer who have specific gene mutations (like BRCA). About 50 men with these mutations will …
Matched conditions: BRCA MUTATION
Sponsor: Institute of Cancer Research, United Kingdom • Aim: Diagnosis
Last updated May 26, 2026 04:10 UTC
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AI reads ovarian ultrasound to spot hidden cancer genes
Diagnosis Recruiting nowThis study is testing whether a computer model can predict if a woman carries a harmful BRCA gene mutation just by looking at ultrasound images of her healthy ovaries. Over 6,400 women will participate, and the goal is to create a simple, non-invasive screening tool. If successfu…
Matched conditions: BRCA MUTATION
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Diagnosis
Last updated May 20, 2026 11:53 UTC