Atypical endometrial hyperplasia
Clinical trials for Atypical endometrial hyperplasia explained in plain language.
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Hormone blockers and letrozole tested to spare uterus in early endometrial cancer
Disease control Recruiting nowResearchers are testing a combination of a gonadotropin-releasing hormone agonist injection and the drug letrozole in obese women with early-stage endometrial cancer that has not responded to progestin. The goal is to see if this hormone-blocking approach can shrink tumors and al…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Phase 2/3 • Sponsor: Xiaojun Chen • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Hormone combo tested as Fertility-Sparing option for early uterine cancer
Disease control Recruiting nowResearchers test whether a combination of GnRHa and letrozole can shrink early endometrial cancer or atypical hyperplasia in non-obese patients who have not responded to progestin therapy. The trial compares this regimen with Diane-35 plus metformin. About 80 participants receive…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Phase 2/3 • Sponsor: Xiaojun Chen • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Hormone showdown: which progestin best tames uterine cancer before surgery?
Disease control Recruiting nowThis study compares two hormone drugs (megestrol acetate and micronized progesterone) in 140 women with endometrial cancer or precancer. Participants take one of the drugs for a short time before their scheduled surgery. Researchers will measure how well each drug slows cancer ce…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Phase 2 • Sponsor: New Mexico Cancer Research Alliance • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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Can weight management plus hormones reverse precancerous uterine changes and preserve fertility?
Disease control Recruiting nowThis study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management pro…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Phase 2/3 • Sponsor: Xiaojun Chen • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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New collagen shot may help young women beat uterine cancer without hysterectomy
Disease control Recruiting nowThis study tests whether injecting a lab-made collagen into the uterus, along with daily hormone pills, can help shrink early-stage endometrial cancer or precancerous growths. The goal is to preserve fertility in women aged 45 or younger. Thirty participants will either receive t…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Phase 2 • Sponsor: Wang Jianliu • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Weight loss program may help women avoid hysterectomy and preserve fertility
Disease control Recruiting nowThis study tests whether adding a behavioral weight loss program to standard hormone therapy helps premenopausal women with obesity and early endometrial cancer or precancer keep their uterus and fertility. About 96 women will receive either the weight loss program plus hormone t…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Swab test could spot hidden uterine cancer early
Diagnosis Recruiting nowThis study is collecting vaginal fluid samples from 4,200 people to develop a new test for endometrial cancer. Participants include those with abnormal uterine bleeding or a recent endometrial cancer diagnosis. The goal is to find biomarkers that could lead to a simple, non-invas…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Sponsor: Exact Sciences Corporation • Aim: Diagnosis
Last updated Aug 29, 2026 00:00 UTC
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Could a vaginal swab detect multiple cancers? mayo clinic launches major study
Diagnosis Recruiting nowThis study aims to develop a screening test that uses a vaginal swab and blood sample to find DNA markers for endometrial, ovarian, and cervical cancers. Researchers at Mayo Clinic will enroll over 3,000 women to see if the test can accurately detect these cancers at an early sta…
Matched conditions: ATYPICAL ENDOMETRIAL HYPERPLASIA
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 12:08 UTC