ANTIPHOSPHOLIPID SYNDROME

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases like rheumatoid arthritis or lupus, who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine is safe and triggers a…

This early-stage study is testing a new cell therapy called YTS109 in 18 adults with severe autoimmune diseases like lupus and Sjogren's syndrome that have not responded to standard treatments. Participants receive a single infusion of these specially designed immune cells. The m…

This study is a registry that collects information on different blood thinner treatments for people with antiphospholipid syndrome who have had an artery clot in the past year. The goal is to see which treatment works best to prevent future clots and bleeding. About 150 adults wi…

This study tests a new treatment using specially engineered immune cells (CAR-NK) from cord blood for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't improved with standard treatments. The goal is to see if a single infusion can safely …

This early-stage study tests a new cell therapy called YTS109 in 18 adults with autoimmune diseases like lupus and Sjogren's syndrome that have not responded to standard treatments. Participants receive a single infusion of these immune cells to see if it is safe and can help con…

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study collects information from children diagnosed with Antiphospholipid Syndrome (APS) to better understand the disease and how it is treated. Researchers will follow up to 50 participants over time to track long-term survival. No new treatments are being tested; the goal i…

This study is creating a global registry to track the safety of direct oral anticoagulants (DOACs) in people with antiphospholipid syndrome (APS) who are not at high risk for blood clots. Researchers will collect data from 500 adults over at least 6 months to monitor rates of new…

This study looks at a protein called annexin A2 on the surface of certain white blood cells in people with antiphospholipid syndrome (APS), a condition that causes abnormal blood clots. Researchers want to see if lower levels of this protein are linked to how the disease works. A…

This study follows 700 pregnant women with lupus or antiphospholipid syndrome to see if certain proteins in the blood can predict serious pregnancy complications like fetal death, preterm birth, or low birth weight. Participants are enrolled early in pregnancy and monitored throu…

This study aims to find out how often antiphospholipid syndrome (APS), a blood clotting disorder, occurs in people aged 65 and older who have had a stroke or mini-stroke. Researchers will test participants' blood for specific antibodies linked to APS and follow their health for 6…