ANTIPHOSPHOLIPID SYNDROME

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine triggers a good immun…

This study is a registry that will track 150 adults with antiphospholipid syndrome who have had an artery clot in the past year. Researchers will compare four different blood-thinning treatment plans to see which works best to prevent new clots and has the fewest bleeding risks. …

This early-stage study tests a new cell treatment called YTS109 in 18 adults with hard-to-treat autoimmune diseases like lupus and Sjogren's syndrome. The main goal is to check if the treatment is safe, and also to see if it helps control the disease. Participants receive a singl…

This study tests a new treatment using specially engineered immune cells (CAR-NK) for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't responded to standard therapies. The treatment aims to control the overactive immune system and reduce…

This early-stage study tests a new cell treatment called YTS109 in about 18 adults with autoimmune diseases like lupus that have not responded to standard therapies. Participants receive a single infusion of these specially designed cells. The main goal is to check safety and see…

This study is building a large database and sample bank from 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will use this information to find links between patient outcomes and biological markers. The goal is to…

This study looks at a protein called annexin A2 on the surface of certain white blood cells in people with antiphospholipid syndrome (APS), a condition that causes abnormal blood clots. Researchers want to see if lower levels of this protein are linked to how the disease works. T…

This study is creating a registry to track the safety of direct oral anticoagulants (DOACs) in people with antiphospholipid syndrome (APS) who are not at high risk for blood clots. Researchers will collect data from 500 adults to see how often blood clots or bleeding occur. The g…

This study collects information from up to 50 children diagnosed with Antiphospholipid Syndrome (APS), a condition that causes abnormal blood clots. Researchers want to learn more about what causes APS and how it is treated. Participants must have had a blood clot and tested posi…

This study follows 700 pregnant women with lupus or antiphospholipid syndrome to see if certain proteins in the blood can predict serious pregnancy complications like fetal death, preterm birth, or low birth weight. Participants are enrolled early in pregnancy and monitored throu…

This study aims to find out how often antiphospholipid syndrome (APS), a blood clotting disorder, occurs in people aged 65 and older who have had a stroke or mini-stroke. Researchers will test participants' blood for specific antibodies linked to APS and follow their health for 6…