ANAL CANCER

This study is testing a new combination of drugs and radiation for people with early-stage anal cancer. The goal is to see if adding an immunotherapy drug (pembrolizumab) to standard chemotherapy and radiation can more effectively eliminate the cancer. Participants will receive s…

This study is observing how well the drug T-DXd works for people with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients in real-world US clinics to see how their tumors respond and how long the …

This study is for people with locally advanced anal cancer that has grown large or spread to nearby lymph nodes. It compares the current standard treatment (chemotherapy plus radiation) against a new approach that adds four cycles of a stronger chemotherapy drug combination *befo…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing a new personalized treatment for advanced cancers caused by HPV. Doctors take a patient's own immune cells, modify them in a lab to better target the cancer, and infuse them back to try to shrink tumors before standard therapy like chemo or surgery. The goal…

This study is testing a new gene therapy for people with advanced cancers caused by HPV. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack HPV-infected cancer cells, and then infuse them back into the patient. The goal is to see if thi…

This study is testing whether offering at-home self-sampling kits makes people more likely to complete their recommended anal cancer screening appointments. It involves about 570 adults at increased risk for anal cancer in three U.S. cities. Researchers want to see if letting peo…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study is testing whether using a vaginal dilator (a tampon-like device) during pelvic radiation treatment for anal cancer can help prevent a common and painful side effect called vaginal stenosis, which is scarring and narrowing of the vagina. The researchers want to see if …

This study aims to understand how radiotherapy for anal cancer affects women's vaginal and sexual health after treatment. Researchers will examine 80 women who finished treatment 6-36 months ago, checking for physical changes and asking about their quality of life and support rec…

This study aims to understand how specific patterns of the human papillomavirus (HPV) are linked to the development of anal cancer or serious pre-cancerous growths over a 10-year period. It involves about 100 people in France who were previously in a related HIV prevention trial.…

This study aims to understand anal cancer risk in men who have sex with men (MSM) who take medication to prevent HIV. Researchers want to know how common precancerous changes are in this group and test different screening methods to detect them early. The study will also measure …

This study aims to understand which types of Human Papillomavirus (HPV) are linked to anal cancer in China and to track the disease's patterns over time. Researchers will collect data from 300 patients already diagnosed with anal cancer across multiple hospitals. The goal is to g…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand how different cancers interact with the body's immune system, particularly focusing on immune cells called T cells. Researchers will collect tissue and blood samples from 1,100 patients with seven types of solid tumors over five years. The goal is to…

This study is testing a blood test to see if it can detect HPV virus DNA in people with anal or cervical cancer before, during, and after they receive standard radiation treatment. Researchers want to learn if the results of this blood test can help predict whether the cancer mig…