ANAL CANCER

This study tests whether a single dose of a patient's own genetically modified immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before standard treatment like chemo-radiation or surgery. About 15 adults with advanced HPV-positive cancers (e.g., cervical, …

This study tests whether giving a powerful chemotherapy (mDCF) before the usual chemoradiation can improve outcomes for people with advanced anal cancer that hasn't spread. About 310 adults with T3-4 or N1 stage disease will be randomly assigned to either standard treatment or th…

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Doctors take a patient's own immune cells, add a special receptor to help them find and attack HPV-infected cancer cells, and give them back. The goal is to shr…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can completely eliminate early-stage anal cancer. About 23 adults with stage I to IIIA anal cancer will receive weekly chemo and radiation plus pembrolizumab, followed by m…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people will take part, and researchers will track whether tumors shrink and how long the benefit lasts. The goal i…

This study tests whether using a vaginal dilator during pelvic radiation therapy can reduce vaginal narrowing (stenosis) in women with anal cancer. About 60 women will be randomly assigned to use the dilator during radiation or not. The goal is to see if this simple approach lowe…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study aims to find out which types of HPV are most common in anal cancer patients in China and describe the disease's impact. Researchers will collect data from 300 people diagnosed with anal cancer at multiple hospitals. The goal is to better understand the virus's role and…

This study looks at whether HPV DNA can be found in the blood of people with HPV-related anal or cervical cancer before, during, and after radiation therapy. Researchers will collect blood samples and tumor tissue to see if changes in HPV DNA levels can help predict if the cancer…

This study looks at how radiotherapy for anal cancer affects women's vaginal and sexual health. Researchers will examine 80 women who completed treatment 6 to 36 months ago, using gynecological exams and questionnaires. The goal is to link radiation dose to vaginal problems and i…

This study follows up with 100 people who took part in the ANRS IPERGAY trial to see how HPV infections relate to anal cancer risk over 10 years. Researchers will use special tests to find HPV molecular signatures and check for high-grade lesions or cancer. The goal is to better …

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are in this group, how well anal swabs can detect them, and how these lesions affect quality of life. About 296 pa…

This study looks at immune cells (T cells) in tumor samples from 1,100 people with cancers like head and neck, ovarian, cervical, lung, and brain cancer. Researchers want to understand how these cells behave, especially a protein called PD-1. No new treatments are tested—only sam…

This study aims to see if allowing people at high risk for anal cancer to collect their own samples at home leads to more completed screenings. Researchers will compare attendance at follow-up appointments between those who self-sample and those who have a healthcare provider col…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…